Search Results

Overview

Uniprot IDQ9H0G5
Protein NameNuclear speckle splicing regulatory protein 1
Gene NameNSRP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 LGKDRKPKYIHNLLK
109 KYIHNLLKAVEIRKK
14 QYGLILPKKTQQLHP
149 AFVTSAYKKKLQERA
15 YGLILPKKTQQLHPV
150 FVTSAYKKKLQERAE
224 FSNEVSSKNRIPQEK
231 KNRIPQEKCILQTDV
281 ETPENDFKHHRSQNH
465 PNSRAKDKFLDQERS
522 RPPEAVSKFAKRNNE
97 NPKLLLGKDRKPKYI

Function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation (PubMed:21296756). Through CCDC118 regulation, may promote pre-adipocyte differentiation (By similarity)

Protein Sequence

10 MAIPGRQYGL 20 ILPKKTQQLH 30 PVLQKPSVFG 40 NDSDDDDETS 50 VSESLQREAA 60 KKQAMKQTKL 70 EIQKALAEDA 80 TVYEYDSIYD 90 EMQKKKEENN 100 PKLLLGKDRK 110 PKYIHNLLKA 120 VEIRKKEQEK 130 RMEKKIQRER 140 EMEKGEFDDK 150 EAFVTSAYKK 160 KLQERAEEEE 170 REKRAAALEA 180 CLDVTKQKDL 190 SGFYRHLLNQ 200 AVGEEEVPKC 210 SFREARSGIK 220 EEKSRGFSNE 230 VSSKNRIPQE 240 KCILQTDVKV 250 EENPDADSDF 260 DAKSSADDEI 270 EETRVNCRRE 280 KVIETPENDF 290 KHHRSQNHSR 300 SPSEERGHST 310 RHHTKGSRTS 320 RGHEKREDQH 330 QQKQSRDQEN 340 HYTDRDYRKE 350 RDSHRHREAS 360 HRDSHWKRHE 370 QEDKPRARDQ 380 RERSDRVWKR 390 EKDREKYSQR 400 EQERDRQQND 410 QNRPSEKGEK 420 EEKSKAKEEH 430 MKVRKERYEN 440 NDKYRDREKR 450 EVGVQSSERN 460 QDRKESSPNS 470 RAKDKFLDQE 480 RSNKMRNMAK 490 DKERNQEKPS 500 NSESSLGAKH 510 RLTEEGQEKG 520 KEQERPPEAV 530 SKFAKRNNEE 540 TVMSARDRYL 550 ARQMARVNAK TYIEKEDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0032502 developmental process
Biological Process GO:0006397 mRNA processing
Biological Process GO:1904179 positive regulation of adipose tissue development
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.