Search Results

Overview

Uniprot IDQ9H0J9
Protein NameProtein mono-ADP-ribosyltransferase PARP12
Gene NamePARP12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
82 CRAHQGSKPGCVGLC

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252)

Protein Sequence

10 MAQAGVVGEV 20 TQVLCAAGGA 30 LELPELRRRL 40 RMGLSADALE 50 RLLRQRGRFV 60 VAVRAGGAAA 70 APERVVLAAS 80 PLRLCRAHQG 90 SKPGCVGLCA 100 QLHLCRFMVY 110 GACKFLRAGK 120 NCRNSHSLTT 130 EHNLSVLRTH 140 GVDHLSYNEL 150 CQLLFQNDPW 160 LLPEICQHYN 170 KGDGPHGSCA 180 FQKQCIKLHI 190 CQYFLQGECK 200 FGTSCKRSHD 210 FSNSENLEKL 220 EKLGMSSDLV 230 SRLPTIYRNA 240 HDIKNKSSAP 250 SRVPPLFVPQ 260 GTSERKDSSG 270 SVSPNTLSQE 280 EGDQICLYHI 290 RKSCSFQDKC 300 HRVHFHLPYR 310 WQFLDRGKWE 320 DLDNMELIEE 330 AYCNPKIERI 340 LCSESASTFH 350 SHCLNFNAMT 360 YGATQARRLS 370 TASSVTKPPH 380 FILTTDWIWY 390 WSDEFGSWQE 400 YGRQGTVHPV 410 TTVSSSDVEK 420 AYLAYCTPGS 430 DGQAATLKFQ 440 AGKHNYELDF 450 KAFVQKNLVY 460 GTTKKVCRRP 470 KYVSPQDVTT 480 MQTCNTKFPG 490 PKSIPDYWDS 500 SALPDPGFQK 510 ITLSSSSEEY 520 QKVWNLFNRT 530 LPFYFVQKIE 540 RVQNLALWEV 550 YQWQKGQMQK 560 QNGGKAVDER 570 QLFHGTSAIF 580 VDAICQQNFD 590 WRVCGVHGTS 600 YGKGSYFARD 610 AAYSHHYSKS 620 DTQTHTMFLA 630 RVLVGEFVRG 640 NASFVRPPAK 650 EGWSNAFYDS 660 CVNSVSDPSI 670 FVIFEKHQVY 680 PEYVIQYTTS 690 SKPSVTPSIL 700 LALGSLFSSR Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0003950 NAD+ poly-ADP-ribosyltransferase activity
Molecular Function GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity
Molecular Function GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
Molecular Function GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity
Molecular Function GO:0016779 nucleotidyltransferase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0070213 protein auto-ADP-ribosylation
Biological Process GO:0070633 transepithelial transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.