Search Results
Overview
| Uniprot ID | Q9H0K4 |
|---|---|
| Protein Name | Radial spoke head protein 6 homolog A |
| Gene Name | RSPH6A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 331 | FRIFLAMKQLVEQQP |
Function
Functions as part of radial spoke complexes in the axoneme of sperm flagella that play an important part in motility. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum
Protein Sequence
10
MGDLPPYPER
20
PAQQPPGRRT
30
SQASQRRHSR
40
DQAQALAADP
50
EERQQIPPDA
60
QRNAPGWSQR
70
GSLSQQENLL
80
MPQVFQAEEA
90
RLGGMEYPSV
100
NTGFPSEFQP
110
QPYSDESRMQ
120
VAELTTSLML
130
QRLQQGQSSL
140
FQQLDPTFQE
150
PPVNPLGQFN
160
LYQTDQFSEG
170
AQHGPYIRDD
180
PALQFLPSEL
190
GFPHYSAQVP
200
EPEPLELAVQ
210
NAKAYLLQTS
220
INCDLSLYEH
230
LVNLLTKILN
240
QRPEDPLSVL
250
ESLNRTTQWE
260
WFHPKLDTLR
270
DDPEMQPTYK
280
MAEKQKALFT
290
RSGGGTEGEQ
300
EMEEEVGETP
310
VPNIMETAFY
320
FEQAGVGLSS
330
DESFRIFLAM
340
KQLVEQQPIH
350
TCRFWGKILG
360
IKRSYLVAEV
370
EFREGEEEAE
380
EEEVEEMTEG
390
GEVMEAHGEE
400
EGEEDEEKAV
410
DIVPKSVWKP
420
PPVIPKEESR
430
SGANKYLYFV
440
CNEPGLPWTR
450
LPHVTPAQIV
460
NARKIKKFFT
470
GYLDTPVVSY
480
PPFPGNEANY
490
LRAQIARISA
500
ATQVSPLGFY
510
QFSEEEGDEE
520
EEGGAGRDSY
530
EENPDFEGIP
540
VLELVDSMAN
550
WVHHTQHILP
560
QGRCTWVNPL
570
QKTEEEEDLG
580
EEEEKADEGP
590
EEVEQEVGPP
600
LLTPLSEDAE
610
IMHLAPWTTR
620
LSCSLCPQYS
630
VAVVRSNLWP
640
GAYAYASGKK
650
FENIYIGWGH
660
KYSPESFNPA
670
LPAPIQQEYP
680
SGPEIMEMSD
690
PTVEEEQALK
700
AAQEQALGAT
710
EEEEEGEEEE
EGEETDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097729 | 9+2 motile cilium |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0001535 | radial spoke head |
| Cellular Component | GO:0036126 | sperm flagellum |
| Biological Process | GO:0035082 | axoneme assembly |
| Biological Process | GO:0003341 | cilium movement |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:1905199 | manchette disassembly |
| Biological Process | GO:0120316 | sperm flagellum assembly |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.