Search Results
Overview
| Uniprot ID | Q9H0S4 |
|---|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX47 |
| Gene Name | DDX47 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | IDHLENTKGFNLRAL |
| 448 | RNKVAGGKMKKRKGR |
Function
Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068)
Protein Sequence
10
MAAPEEHDSP
20
TEASQPIVEE
30
EETKTFKDLG
40
VTDVLCEACD
50
QLGWTKPTKI
60
QIEAIPLALQ
70
GRDIIGLAET
80
GSGKTGAFAL
90
PILNALLETP
100
QRLFALVLTP
110
TRELAFQISE
120
QFEALGSSIG
130
VQSAVIVGGI
140
DSMSQSLALA
150
KKPHIIIATP
160
GRLIDHLENT
170
KGFNLRALKY
180
LVMDEADRIL
190
NMDFETEVDK
200
ILKVIPRDRK
210
TFLFSATMTK
220
KVQKLQRAAL
230
KNPVKCAVSS
240
KYQTVEKLQQ
250
YYIFIPSKFK
260
DTYLVYILNE
270
LAGNSFMIFC
280
STCNNTQRTA
290
LLLRNLGFTA
300
IPLHGQMSQS
310
KRLGSLNKFK
320
AKARSILLAT
330
DVASRGLDIP
340
HVDVVVNFDI
350
PTHSKDYIHR
360
VGRTARAGRS
370
GKAITFVTQY
380
DVELFQRIEH
390
LIGKKLPGFP
400
TQDDEVMMLT
410
ERVAEAQRFA
420
RMELREHGEK
430
KKRSREDAGD
440
NDDTEGAIGV
450
RNKVAGGKMK
KRKGR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Biological Process | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.