Search Results
Overview
| Uniprot ID | Q9H0W8 |
|---|---|
| Protein Name | Nonsense-mediated mRNA decay factor SMG9 |
| Gene Name | SMG9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | IERRRRWKEPGSGGP |
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity)
Protein Sequence
10
MSESGHSQPG
20
LYGIERRRRW
30
KEPGSGGPQN
40
LSGPGGRERD
50
YIAPWERERR
60
DASEETSTSV
70
MQKTPIILSK
80
PPAERSKQPP
90
PPTAPAAPPA
100
PAPLEKPIVL
110
MKPREEGKGP
120
VAVTGASTPE
130
GTAPPPPAAP
140
APPKGEKEGQ
150
RPTQPVYQIQ
160
NRGMGTAAPA
170
AMDPVVGQAK
180
LLPPERMKHS
190
IKLVDDQMNW
200
CDSAIEYLLD
210
QTDVLVVGVL
220
GLQGTGKSMV
230
MSLLSANTPE
240
EDQRTYVFRA
250
QSAEMKERGG
260
NQTSGIDFFI
270
TQERIVFLDT
280
QPILSPSILD
290
HLINNDRKLP
300
PEYNLPHTYV
310
EMQSLQIAAF
320
LFTVCHVVIV
330
VQDWFTDLSL
340
YRFLQTAEMV
350
KPSTPSPSHE
360
SSSSSGSDEG
370
TEYYPHLVFL
380
QNKARREDFC
390
PRKLRQMHLM
400
IDQLMAHSHL
410
RYKGTLSMLQ
420
CNVFPGLPPD
430
FLDSEVNLFL
440
VPFMDSEAES
450
ENPPRAGPGS
460
SPLFSLLPGY
470
RGHPSFQSLV
480
SKLRSQVMSM
490
ARPQLSHTIL
500
TEKNWFHYAA
510
RIWDGVRKSS
520
ALAEYSRLLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0001654 | eye development |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| Biological Process | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.