Search Results

Overview

Uniprot ID	Q9H0W9
Protein Name	Beta-keto L-gulonate decarboxylase
Gene Name	BKGD
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
244	WLHFYEMKAPLVCLP
307	LYRIDQPKETHSIGR
51	EPFTFPVKGICGKTR
56	PVKGICGKTRIAEVG
76	LPLVNQKKVYDLNKI

Function

Catalyzes the decarboxylation of 3-dehydro-L-gulonate to produce L-xylulose, used in the pentose pathway (PubMed:40737316). Exhibits ester hydrolase activity on p-nitrophenyl acetate, in vitro (PubMed:16522806). Regulates DNA damage and repair by regulating HIF1A degradation via chaperone-mediated autophagy (CMA) (PubMed:37277441)

Protein Sequence

10 MACAEFSFHV 20 PSLEELAGVM 30 QKGLKDNFAD 40 VQVSVVDCPD 50 LTKEPFTFPV 60 KGICGKTRIA 70 EVGGVPYLLP 80 LVNQKKVYDL 90 NKIAKEIKLP 100 GAFILGAGAG 110 PFQTLGFNSE 120 FMPVIQTESE 130 HKPPVNGSYF 140 AHVNPADGGC 150 LLEKYSEKCH 160 DFQCALLANL 170 FASEGQPGKV 180 IEVKAKRRTG 190 PLNFVTCMRE 200 TLEKHYGNKP 210 IGMGGTFIIQ 220 KGKVKSHIMP 230 AEFSSCPLNS 240 DEEVNKWLHF 250 YEMKAPLVCL 260 PVFVSRDPGF 270 DLRLEHTHFF 280 SRHGEGGHYH 290 YDTTPDIVEY 300 LGYFLPAEFL 310 YRIDQPKETH SIGRD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0047842	dehydro-L-gulonate decarboxylase activity
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006282	regulation of DNA repair

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.