Overview
| Uniprot ID | Q9H0X9 |
|---|
| Protein Name | Oxysterol-binding protein-related protein 5 |
|---|
| Gene Name | OSBPL5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 84 |
RLCNGSDKECVSPTA |
Function
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193)
Protein Sequence
10
MKEEAFLRRR
20
FSLCPPSSTP
30
QKVDPRKLTR
40
NLLLSGDNEL
50
YPLSPGKDME
60
PNGPSLPRDE
70
GPPTPSSATK
80
VPPAEYRLCN
90
GSDKECVSPT
100
ARVTKKETLK
110
AQKENYRQEK
120
KRATRQLLSA
130
LTDPSVVIMA
140
DSLKIRGTLK
150
SWTKLWCVLK
160
PGVLLIYKTP
170
KVGQWVGTVL
180
LHCCELIERP
190
SKKDGFCFKL
200
FHPLDQSVWA
210
VKGPKGESVG
220
SITQPLPSSY
230
LIFRAASESD
240
GRCWLDALEL
250
ALRCSSLLRL
260
GTCKPGRDGE
270
PGTSPDASPS
280
SLCGLPASAT
290
VHPDQDLFPL
300
NGSSLENDAF
310
SDKSERENPE
320
ESDTETQDHS
330
RKTESGSDQS
340
ETPGAPVRRG
350
TTYVEQVQEE
360
LGELGEASQV
370
ETVSEENKSL
380
MWTLLKQLRP
390
GMDLSRVVLP
400
TFVLEPRSFL
410
NKLSDYYYHA
420
DLLSRAAVEE
430
DAYSRMKLVL
440
RWYLSGFYKK
450
PKGIKKPYNP
460
ILGETFRCCW
470
FHPQTDSRTF
480
YIAEQVSHHP
490
PVSAFHVSNR
500
KDGFCISGSI
510
TAKSRFYGNS
520
LSALLDGKAT
530
LTFLNRAEDY
540
TLTMPYAHCK
550
GILYGTMTLE
560
LGGKVTIECA
570
KNNFQAQLEF
580
KLKPFFGGST
590
SINQISGKIT
600
SGEEVLASLS
610
GHWDRDVFIK
620
EEGSGSSALF
630
WTPSGEVRRQ
640
RLRQHTVPLE
650
EQTELESERL
660
WQHVTRAISK
670
GDQHRATQEK
680
FALEEAQRQR
690
ARERQESLMP
700
WKPQLFHLDP
710
ITQEWHYRYE
720
DHSPWDPLKD
730
IAQFEQDGIL
740
RTLQQEAVAR
750
QTTFLGSPGP
760
RHERSGPDQR
770
LRKASDQPSG
780
HSQATESSGS
790
TPESCPELSD
800
EEQDGDFVPG
810
GESPCPRCRK
820
EARRLQALHE
830
AILSIREAQQ
840
ELHRHLSAML
850
SSTARAAQAP
860
TPGLLQSPRS
870
WFLLCVFLAC
QLFINHILK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0140268 |
endoplasmic reticulum-plasma membrane contact site |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:1990351 |
transporter complex |
| Molecular Function |
GO:0015485 |
cholesterol binding |
| Molecular Function |
GO:0008142 |
oxysterol binding |
| Molecular Function |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Molecular Function |
GO:0140343 |
phosphatidylserine transfer activity |
| Molecular Function |
GO:0005548 |
phospholipid transporter activity |
| Biological Process |
GO:0008203 |
cholesterol metabolic process |
| Biological Process |
GO:0030301 |
cholesterol transport |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:0120010 |
intermembrane phospholipid transfer |
| Biological Process |
GO:0036150 |
phosphatidylserine acyl-chain remodeling |
| Biological Process |
GO:0015914 |
phospholipid transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.