Search Results

Overview

Uniprot IDQ9H147
Protein NameDeoxynucleotidyltransferase terminal-interacting protein 1
Gene NameDNTTIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
134 LLFSDGEKVIPRLTH
190 AGMVWKPKSCEPIRR
221 VLGSRANKALGMGGT

Function

Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA

Protein Sequence

10 MGATGDAEQP 20 RGPSGAERGG 30 LELGDAGAAG 40 QLVLTNPWNI 50 MIKHRQVQRR 60 GRRSQMTTSF 70 TDPAISMDLL 80 RAVLQPSINE 90 EIQTVFNKYM 100 KFFQKAALNV 110 RDNVGEEVDA 120 EQLIQEACRS 130 CLEQAKLLFS 140 DGEKVIPRLT 150 HELPGIKRGR 160 QAEEECAHRG 170 SPLPKKRKGR 180 PPGHILSSDR 190 AAAGMVWKPK 200 SCEPIRREGP 210 KWDPARLNES 220 TTFVLGSRAN 230 KALGMGGTRG 240 RIYIKHPHLF 250 KYAADPQDKH 260 WLAEQHHMRA 270 TGGKMAYLLI 280 EEDIRDLAAS 290 DDYRGCLDLK 300 LEELKSFVLP 310 SWMVEKMRKY 320 METLRTENEH RAVEAPPQT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045995 regulation of embryonic development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.