Search Results
Overview
| Uniprot ID | Q9H165 |
|---|---|
| Protein Name | BCL11 transcription factor A |
| Gene Name | BCL11A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 421 | CTQASKLKRHMKTHM |
| 620 | ASGGLSKKLLLGSPS |
| 752 | EYCGKVFKNCSNLTV |
| 784 | YACAQSSKLTRHMKT |
Function
Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity)
Protein Sequence
10
MSRRKQGKPQ
20
HLSKREFSPE
30
PLEAILTDDE
40
PDHGPLGAPE
50
GDHDLLTCGQ
60
CQMNFPLGDI
70
LIFIEHKRKQ
80
CNGSLCLEKA
90
VDKPPSPSPI
100
EMKKASNPVE
110
VGIQVTPEDD
120
DCLSTSSRGI
130
CPKQEHIADK
140
LLHWRGLSSP
150
RSAHGALIPT
160
PGMSAEYAPQ
170
GICKDEPSSY
180
TCTTCKQPFT
190
SAWFLLQHAQ
200
NTHGLRIYLE
210
SEHGSPLTPR
220
VGIPSGLGAE
230
CPSQPPLHGI
240
HIADNNPFNL
250
LRIPGSVSRE
260
ASGLAEGRFP
270
PTPPLFSPPP
280
RHHLDPHRIE
290
RLGAEEMALA
300
THHPSAFDRV
310
LRLNPMAMEP
320
PAMDFSRRLR
330
ELAGNTSSPP
340
LSPGRPSPMQ
350
RLLQPFQPGS
360
KPPFLATPPL
370
PPLQSAPPPS
380
QPPVKSKSCE
390
FCGKTFKFQS
400
NLVVHRRSHT
410
GEKPYKCNLC
420
DHACTQASKL
430
KRHMKTHMHK
440
SSPMTVKSDD
450
GLSTASSPEP
460
GTSDLVGSAS
470
SALKSVVAKF
480
KSENDPNLIP
490
ENGDEEEEED
500
DEEEEEEEEE
510
EEEELTESER
520
VDYGFGLSLE
530
AARHHENSSR
540
GAVVGVGDES
550
RALPDVMQGM
560
VLSSMQHFSE
570
AFHQVLGEKH
580
KRGHLAEAEG
590
HRDTCDEDSV
600
AGESDRIDDG
610
TVNGRGCSPG
620
ESASGGLSKK
630
LLLGSPSSLS
640
PFSKRIKLEK
650
EFDLPPAAMP
660
NTENVYSQWL
670
AGYAASRQLK
680
DPFLSFGDSR
690
QSPFASSSEH
700
SSENGSLRFS
710
TPPGELDGGI
720
SGRSGTGSGG
730
STPHISGPGP
740
GRPSSKEGRR
750
SDTCEYCGKV
760
FKNCSNLTVH
770
RRSHTGERPY
780
KCELCNYACA
790
QSSKLTRHMK
800
THGQVGKDVY
810
KCEICKMPFS
820
VYSTLEKHMK
830
KWHSDRVLNN
DIKTE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0042382 | paraspeckles |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0016514 | SWI/SNF complex |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0001067 | transcription regulatory region nucleic acid binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:1905232 | cellular response to L-glutamate |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0030517 | negative regulation of axon extension |
| Biological Process | GO:2000173 | negative regulation of branching morphogenesis of a nerve |
| Biological Process | GO:0048671 | negative regulation of collateral sprouting |
| Biological Process | GO:2000171 | negative regulation of dendrite development |
| Biological Process | GO:1903860 | negative regulation of dendrite extension |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:1904800 | negative regulation of neuron remodeling |
| Biological Process | GO:0032463 | negative regulation of protein homooligomerization |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048672 | positive regulation of collateral sprouting |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0050773 | regulation of dendrite development |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A