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Overview

Uniprot IDQ9H1A4
Protein NameAnaphase-promoting complex subunit 1
Gene NameANAPC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
310 AHLRSLSKGDSPVTS
905 RITIAPQKLQVEQEE

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861)

Protein Sequence

10 MSNFYEERTT 20 MIAARDLQEF 30 VPFGRDHCKH 40 HPNALNLQLR 50 QLQPASELWS 60 SDGAAGLVGS 70 LQEVTIHEKQ 80 KESWQLRKGV 90 SEIGEDVDYD 100 EELYVAGNMV 110 IWSKGSKSQA 120 LAVYKAFTVD 130 SPVQQALWCD 140 FIISQDKSEK 150 AYSSNEVEKC 160 ICILQSSCIN 170 MHSIEGKDYI 180 ASLPFQVANV 190 WPTKYGLLFE 200 RSASSHEVPP 210 GSPREPLPTM 220 FSMLHPLDEI 230 TPLVCKSGSL 240 FGSSRVQYVV 250 DHAMKIVFLN 260 TDPSIVMTYD 270 AVQNVHSVWT 280 LRRVKSEEEN 290 VVLKFSEQGG 300 TPQNVATSSS 310 LTAHLRSLSK 320 GDSPVTSPFQ 330 NYSSIHSQSR 340 STSSPSLHSR 350 SPSISNMAAL 360 SRAHSPALGV 370 HSFSGVQRFN 380 ISSHNQSPKR 390 HSISHSPNSN 400 SNGSFLAPET 410 EPIVPELCID 420 HLWTETITNI 430 REKNSQASKV 440 FITSDLCGQK 450 FLCFLVESQL 460 QLRCVKFQES 470 NDKTQLIFGS 480 VTNIPAKDAA 490 PVEKIDTMLV 500 LEGSGNLVLY 510 TGVVRVGKVF 520 IPGLPAPSLT 530 MSNTMPRPST 540 PLDGVSTPKP 550 LSKLLGSLDE 560 VVLLSPVPEL 570 RDSSKLHDSL 580 YNEDCTFQQL 590 GTYIHSIRDP 600 VHNRVTLELS 610 NGSMVRITIP 620 EIATSELVQT 630 CLQAIKFILP 640 KEIAVQMLVK 650 WYNVHSAPGG 660 PSYHSEWNLF 670 VTCLMNMMGY 680 NTDRLAWTRN 690 FDFEGSLSPV 700 IAPKKARPSE 710 TGSDDDWEYL 720 LNSDYHQNVE 730 SHLLNRSLCL 740 SPSEASQMKD 750 EDFSQNLSLD 760 SSTLLFTHIP 770 AIFFVLHLVY 780 EELKLNTLMG 790 EGICSLVELL 800 VQLARDLKLG 810 PYVDHYYRDY 820 PTLVRTTGQV 830 CTIDPGQTGF 840 MHHPSFFTSE 850 PPSIYQWVSS 860 CLKGEGMPPY 870 PYLPGICERS 880 RLVVLSIALY 890 ILGDESLVSD 900 ESSQYLTRIT 910 IAPQKLQVEQ 920 EENRFSFRHS 930 TSVSSLAERL 940 VVWMTNVGFT 950 LRDLETLPFG 960 IALPIRDAIY 970 HCREQPASDW 980 PEAVCLLIGR 990 QDLSKQACEG 1000 NLPKGKSVLS 1010 SDVPSGTETE 1020 EEDDGMNDMN 1030 HEVMSLIWSE 1040 DLRVQDVRRL 1050 LQSAHPVRVN 1060 VVQYPELSDH 1070 EFIEEKENRL 1080 LQLCQRTMAL 1090 PVGRGMFTLF 1100 SYHPVPTEPL 1110 PIPKLNLTGR 1120 APPRNTTVDL 1130 NSGNIDVPPN 1140 MTSWASFHNG 1150 VAAGLKIAPA 1160 SQIDSAWIVY 1170 NKPKHAELAN 1180 EYAGFLMALG 1190 LNGHLTKLAT 1200 LNIHDYLTKG 1210 HEMTSIGLLL 1220 GVSAAKLGTM 1230 DMSITRLLSI 1240 HIPALLPPTS 1250 TELDVPHNVQ 1260 VAAVVGIGLV 1270 YQGTAHRHTA 1280 EVLLAEIGRP 1290 PGPEMEYCTD 1300 RESYSLAAGL 1310 ALGMVCLGHG 1320 SNLIGMSDLN 1330 VPEQLYQYMV 1340 GGHRRFQTGM 1350 HREKHKSPSY 1360 QIKEGDTINV 1370 DVTCPGATLA 1380 LAMIYLKTNN 1390 RSIADWLRAP 1400 DTMYLLDFVK 1410 PEFLLLRTLA 1420 RCLILWDDIL 1430 PNSKWVDSNV 1440 PQIIRENSIS 1450 LSEIELPCSE 1460 DLNLETLSQA 1470 HVYIIAGACL 1480 SLGFRFAGSE 1490 NLSAFNCLHK 1500 FAKDFMTYLS 1510 APNASVTGPH 1520 NLETCLSVVL 1530 LSLAMVMAGS 1540 GNLKVLQLCR 1550 FLHMKTGGEM 1560 NYGFHLAHHM 1570 ALGLLFLGGG 1580 RYSLSTSNSS 1590 IAALLCALYP 1600 HFPAHSTDNR 1610 YHLQALRHLY 1620 VLAAEPRLLV 1630 PVDVDTNTPC 1640 YALLEVTYKG 1650 TQWYEQTKEE 1660 LMAPTLLPEL 1670 HLLKQIKVKG 1680 PRYWELLIDL 1690 SKGTQHLKSI 1700 LSKDGVLYVK 1710 LRAGQLSYKE 1720 DPMGWQSLLA 1730 QTVANRNSEA 1740 RAFKPETISA 1750 FTSDPALLSF 1760 AEYFCKPTVN 1770 MGQKQEILDL 1780 FSSVLYECVT 1790 QETPEMLPAY 1800 IAMDQAIRRL 1810 GRREMSETSE 1820 LWQIKLVLEF 1830 FSSRSHQERL 1840 QNHPKRGLFM 1850 NSEFLPVVKC 1860 TIDNTLDQWL 1870 QVGGDMCVHA 1880 YLSGQPLEES 1890 QLSMLACFLV 1900 YHSVPAPQHL 1910 PPIGLEGSTS 1920 FAELLFKFKQ 1930 LKMPVRALLR 1940 LAPLLLGNPQ PMVM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005680 anaphase-promoting complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0051301 cell division
Biological Process GO:0007091 metaphase/anaphase transition of mitotic cell cycle
Biological Process GO:0141198 protein branched polyubiquitination
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0051445 regulation of meiotic cell cycle
Biological Process GO:0007346 regulation of mitotic cell cycle

Reference

PMID: N/A