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Overview

Uniprot IDQ9H1B7
Protein NameProbable E3 ubiquitin-protein ligase IRF2BPL
Gene NameIRF2BPL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
545 AASLRKRKASPEPPD

Function

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)

Protein Sequence

10 MSAAQVSSSR 20 RQSCYLCDLP 30 RMPWAMIWDF 40 SEPVCRGCVN 50 YEGADRIEFV 60 IETARQLKRA 70 HGCFQDGRSP 80 GPPPPVGVKT 90 VALSAKEAAA 100 AAAAAAAAAA 110 AAQQQQQQQQ 120 QQQQQQQQQQ 130 QQQQQQQLNH 140 VDGSSKPAVL 150 AAPSGLERYG 160 LSAAAAAAAA 170 AAAAVEQRSR 180 FEYPPPPVSL 190 GSSSHTARLP 200 NGLGGPNGFP 210 KPTPEEGPPE 220 LNRQSPNSSS 230 AAASVASRRG 240 THGGLVTGLP 250 NPGGGGGPQL 260 TVPPNLLPQT 270 LLNGPASAAV 280 LPPPPPHALG 290 SRGPPTPAPP 300 GAPGGPACLG 310 GTPGVSATSS 320 SASSSTSSSV 330 AEVGVGAGGK 340 RPGSVSSTDQ 350 ERELKEKQRN 360 AEALAELSES 370 LRNRAEEWAS 380 KPKMVRDTLL 390 TLAGCTPYEV 400 RFKKDHSLLG 410 RVFAFDAVSK 420 PGMDYELKLF 430 IEYPTGSGNV 440 YSSASGVAKQ 450 MYQDCMKDFG 460 RGLSSGFKYL 470 EYEKKHGSGD 480 WRLLGDLLPE 490 AVRFFKEGVP 500 GADMLPQPYL 510 DASCPMLPTA 520 LVSLSRAPSA 530 PPGTGALPPA 540 APSGRGAAAS 550 LRKRKASPEP 560 PDSAEGALKL 570 GEEQQRQQWM 580 ANQSEALKLT 590 MSAGGFAAPG 600 HAAGGPPPPP 610 PPLGPHSNRT 620 TPPESAPQNG 630 PSPMAALMSV 640 ADTLGTAHSP 650 KDGSSVHSTT 660 ASARRNSSSP 670 VSPASVPGQR 680 RLASRNGDLN 690 LQVAPPPPSA 700 HPGMDQVHPQ 710 NIPDSPMANS 720 GPLCCTICHE 730 RLEDTHFVQC 740 PSVPSHKFCF 750 PCSRESIKAQ 760 GATGEVYCPS 770 GEKCPLVGSN 780 VPWAFMQGEI 790 ATILAGDVKV KKERDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0046543 development of secondary female sexual characteristics
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007399 nervous system development
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016567 protein ubiquitination

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.