Search Results

Overview

Uniprot IDQ9H251
Protein NameCadherin-23
Gene NameCDH23
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1805 EGVLRVRKDVELDRE

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing

Protein Sequence

10 MGRHVATSCH 20 VAWLLVLISG 30 CWGQVNRLPF 40 FTNHFFDTYL 50 LISEDTPVGS 60 SVTQLLAQDM 70 DNDPLVFGVS 80 GEEASRFFAV 90 EPDTGVVWLR 100 QPLDRETKSE 110 FTVEFSVSDH 120 QGVITRKVNI 130 QVGDVNDNAP 140 TFHNQPYSVR 150 IPENTPVGTP 160 IFIVNATDPD 170 LGAGGSVLYS 180 FQPPSQFFAI 190 DSARGIVTVI 200 RELDYETTQA 210 YQLTVNATDQ 220 DKTRPLSTLA 230 NLAIIITDVQ 240 DMDPIFINLP 250 YSTNIYEHSP 260 PGTTVRIITA 270 IDQDKGRPRG 280 IGYTIVSGNT 290 NSIFALDYIS 300 GVLTLNGLLD 310 RENPLYSHGF 320 ILTVKGTELN 330 DDRTPSDATV 340 TTTFNILVID 350 INDNAPEFNS 360 SEYSVAITEL 370 AQVGFALPLF 380 IQVVDKDENL 390 GLNSMFEVYL 400 VGNNSHHFII 410 SPTSVQGKAD 420 IRIRVAIPLD 430 YETVDRYDFD 440 LFANESVPDH 450 VGYAKVKITL 460 INENDNRPIF 470 SQPLYNISLY 480 ENVTVGTSVL 490 TVLATDNDAG 500 TFGEVSYFFS 510 DDPDRFSLDK 520 DTGLIMLIAR 530 LDYELIQRFT 540 LTIIARDGGG 550 EETTGRVRIN 560 VLDVNDNVPT 570 FQKDAYVGAL 580 RENEPSVTQL 590 VRLRATDEDS 600 PPNNQITYSI 610 VSASAFGSYF 620 DISLYEGYGV 630 ISVSRPLDYE 640 QISNGLIYLT 650 VMAMDAGNPP 660 LNSTVPVTIE 670 VFDENDNPPT 680 FSKPAYFVSV 690 VENIMAGATV 700 LFLNATDLDR 710 SREYGQESII 720 YSLEGSTQFR 730 INARSGEITT 740 TSLLDRETKS 750 EYILIVRAVD 760 GGVGHNQKTG 770 IATVNITLLD 780 INDNHPTWKD 790 APYYINLVEM 800 TPPDSDVTTV 810 VAVDPDLGEN 820 GTLVYSIQPP 830 NKFYSLNSTT 840 GKIRTTHAML 850 DRENPDPHEA 860 ELMRKIVVSV 870 TDCGRPPLKA 880 TSSATVFVNL 890 LDLNDNDPTF 900 QNLPFVAEVL 910 EGIPAGVSIY 920 QVVAIDLDEG 930 LNGLVSYRMP 940 VGMPRMDFLI 950 NSSSGVVVTT 960 TELDRERIAE 970 YQLRVVASDA 980 GTPTKSSTST 990 LTIHVLDVND 1000 ETPTFFPAVY 1010 NVSVSEDVPR 1020 EFRVVWLNCT 1030 DNDVGLNAEL 1040 SYFITGGNVD 1050 GKFSVGYRDA 1060 VVRTVVGLDR 1070 ETTAAYMLIL 1080 EAIDNGPVGK 1090 RHTGTATVFV 1100 TVLDVNDNRP 1110 IFLQSSYEAS 1120 VPEDIPEGHS 1130 ILQLKATDAD 1140 EGEFGRVWYR 1150 ILHGNHGNNF 1160 RIHVSNGLLM 1170 RGPRPLDRER 1180 NSSHVLIVEA 1190 YNHDLGPMRS 1200 SVRVIVYVED 1210 INDEAPVFTQ 1220 QQYSRLGLRE 1230 TAGIGTSVIV 1240 VQATDRDSGD 1250 GGLVNYRILS 1260 GAEGKFEIDE 1270 STGLIITVNY 1280 LDYETKTSYM 1290 MNVSATDQAP 1300 PFNQGFCSVY 1310 ITLLNELDEA 1320 VQFSNASYEA 1330 AILENLALGT 1340 EIVRVQAYSI 1350 DNLNQITYRF 1360 NAYTSTQAKA 1370 LFKIDAITGV 1380 ITVQGLVDRE 1390 KGDFYTLTVV 1400 ADDGGPKVDS 1410 TVKVYITVLD 1420 ENDNSPRFDF 1430 TSDSAVSIPE 1440 DCPVGQRVAT 1450 VKAWDPDAGS 1460 NGQVVFSLAS 1470 GNIAGAFEIV 1480 TTNDSIGEVF 1490 VARPLDREEL 1500 DHYILQVVAS 1510 DRGTPPRKKD 1520 HILQVTILDI 1530 NDNPPVIESP 1540 FGYNVSVNEN 1550 VGGGTAVVQV 1560 RATDRDIGIN 1570 SVLSYYITEG 1580 NKDMAFRMDR 1590 ISGEIATRPA 1600 PPDRERQSFY 1610 HLVATVEDEG 1620 TPTLSATTHV 1630 YVTIVDENDN 1640 APMFQQPHYE 1650 VLLDEGPDTL 1660 NTSLITIQAL 1670 DLDEGPNGTV 1680 TYAIVAGNIV 1690 NTFRIDRHMG 1700 VITAAKELDY 1710 EISHGRYTLI 1720 VTATDQCPIL 1730 SHRLTSTTTV 1740 LVNVNDINDN 1750 VPTFPRDYEG 1760 PFEVTEGQPG 1770 PRVWTFLAHD 1780 RDSGPNGQVE 1790 YSIMDGDPLG 1800 EFVISPVEGV 1810 LRVRKDVELD 1820 RETIAFYNLT 1830 ICARDRGMPP 1840 LSSTMLVGIR 1850 VLDINDNDPV 1860 LLNLPMNITI 1870 SENSPVSSFV 1880 AHVLASDADS 1890 GCNARLTFNI 1900 TAGNRERAFF 1910 INATTGIVTV 1920 NRPLDRERIP 1930 EYKLTISVKD 1940 NPENPRIARR 1950 DYDLLLIFLS 1960 DENDNHPLFT 1970 KSTYQAEVME 1980 NSPAGTPLTV 1990 LNGPILALDA 2000 DQDIYAVVTY 2010 QLLGAQSGLF 2020 DINSSTGVVT 2030 VRSGVIIDRE 2040 AFSPPILELL 2050 LLAEDIGLLN 2060 STAHLLITIL 2070 DDNDNRPTFS 2080 PATLTVHLLE 2090 NCPPGFSVLQ 2100 VTATDEDSGL 2110 NGELVYRIEA 2120 GAQDRFLIHL 2130 VTGVIRVGNA 2140 TIDREEQESY 2150 RLTVVATDRG 2160 TVPLSGTAIV 2170 TILIDDINDS 2180 RPEFLNPIQT 2190 VSVLESAEPG 2200 TVIANITAID 2210 HDLNPKLEYH 2220 IVGIVAKDDT 2230 DRLVPNQEDA 2240 FAVNINTGSV 2250 MVKSPMNREL 2260 VATYEVTLSV 2270 IDNASDLPER 2280 SVSVPNAKLT 2290 VNVLDVNDNT 2300 PQFKPFGITY 2310 YMERILEGAT 2320 PGTTLIAVAA 2330 VDPDKGLNGL 2340 VTYTLLDLVP 2350 PGYVQLEDSS 2360 AGKVIANRTV 2370 DYEEVHWLNF 2380 TVRASDNGSP 2390 PRAAEIPVYL 2400 EIVDINDNNP 2410 IFDQPSYQEA 2420 VFEDVPVGTI 2430 ILTVTATDAD 2440 SGNFALIEYS 2450 LGDGESKFAI 2460 NPTTGDIYVL 2470 SSLDREKKDH 2480 YILTALAKDN 2490 PGDVASNRRE 2500 NSVQVVIQVL 2510 DVNDCRPQFS 2520 KPQFSTSVYE 2530 NEPAGTSVIT 2540 MMATDQDEGP 2550 NGELTYSLEG 2560 PGVEAFHVDM 2570 DSGLVTTQRP 2580 LQSYEKFSLT 2590 VVATDGGEPP 2600 LWGTTMLLVE 2610 VIDVNDNRPV 2620 FVRPPNGTIL 2630 HIREEIPLRS 2640 NVYEVYATDK 2650 DEGLNGAVRY 2660 SFLKTAGNRD 2670 WEFFIIDPIS 2680 GLIQTAQRLD 2690 RESQAVYSLI 2700 LVASDLGQPV 2710 PYETMQPLQV 2720 ALEDIDDNEP 2730 LFVRPPKGSP 2740 QYQLLTVPEH 2750 SPRGTLVGNV 2760 TGAVDADEGP 2770 NAIVYYFIAA 2780 GNEEKNFHLQ 2790 PDGCLLVLRD 2800 LDREREAIFS 2810 FIVKASSNRS 2820 WTPPRGPSPT 2830 LDLVADLTLQ 2840 EVRVVLEDIN 2850 DQPPRFTKAE 2860 YTAGVATDAK 2870 VGSELIQVLA 2880 LDADIGNNSL 2890 VFYSILAIHY 2900 FRALANDSED 2910 VGQVFTMGSM 2920 DGILRTFDLF 2930 MAYSPGYFVV 2940 DIVARDLAGH 2950 NDTAIIGIYI 2960 LRDDQRVKIV 2970 INEIPDRVRG 2980 FEEEFIHLLS 2990 NITGAIVNTD 3000 NVQFHVDKKG 3010 RVNFAQTELL 3020 IHVVNRDTNR 3030 ILDVDRVIQM 3040 IDENKEQLRN 3050 LFRNYNVLDV 3060 QPAISVRLPD 3070 DMSALQMAII 3080 VLAILLFLAA 3090 MLFVLMNWYY 3100 RTVHKRKLKA 3110 IVAGSAGNRG 3120 FIDIMDMPNT 3130 NKYSFDGANP 3140 VWLDPFCRNL 3150 ELAAQAEHED 3160 DLPENLSEIA 3170 DLWNSPTRTH 3180 GTFGREPAAV 3190 KPDDDRYLRA 3200 AIQEYDNIAK 3210 LGQIIREGPI 3220 KGSLLKVVLE 3230 DYLRLKKLFA 3240 QRMVQKASSC 3250 HSSISELIQT 3260 ELDEEPGDHS 3270 PGQGSLRFRH 3280 KPPVELKGPD 3290 GIHVVHGSTG 3300 TLLATDLNSL 3310 PEEDQKGLGR 3320 SLETLTAAEA 3330 TAFERNARTE 3340 SAKSTPLHKL 3350 RDVIMETPLE ITEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016342 catenin complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0098683 cochlear hair cell ribbon synapse
Cellular Component GO:0060091 kinocilium
Cellular Component GO:0016020 membrane
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0098684 photoreceptor ribbon synapse
Cellular Component GO:0032420 stereocilium
Cellular Component GO:0032426 stereocilium tip
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0016339 calcium-dependent cell-cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0050957 equilibrioception
Biological Process GO:0007156 homophilic cell-cell adhesion
Biological Process GO:0031175 neuron projection development
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0050953 sensory perception of light stimulus
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0007601 visual perception

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.