Search Results
Overview
| Uniprot ID | Q9H2A2 |
|---|---|
| Protein Name | 2-aminomuconic semialdehyde dehydrogenase |
| Gene Name | ALDH8A1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 248 | QLSAPHCKKLSLELG |
| 416 | IERANNVKYGLAATV |
| 44 | CRVPNSGKDEIEAAV |
| 97 | AESKDQGKTLALART |
Function
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation
Protein Sequence
10
MAGTNALLML
20
ENFIDGKFLP
30
CSSYIDSYDP
40
STGEVYCRVP
50
NSGKDEIEAA
60
VKAAREAFPS
70
WSSRSPQERS
80
RVLNQVADLL
90
EQSLEEFAQA
100
ESKDQGKTLA
110
LARTMDIPRS
120
VQNFRFFASS
130
SLHHTSECTQ
140
MDHLGCMHYT
150
VRAPVGVAGL
160
ISPWNLPLYL
170
LTWKIAPAMA
180
AGNTVIAKPS
190
ELTSVTAWML
200
CKLLDKAGVP
210
PGVVNIVFGT
220
GPRVGEALVS
230
HPEVPLISFT
240
GSQPTAERIT
250
QLSAPHCKKL
260
SLELGGKNPA
270
IIFEDANLDE
280
CIPATVRSSF
290
ANQGEICLCT
300
SRIFVQKSIY
310
SEFLKRFVEA
320
TRKWKVGIPS
330
DPLVSIGALI
340
SKAHLEKVRS
350
YVKRALAEGA
360
QIWCGEGVDK
370
LSLPARNQAG
380
YFMLPTVITD
390
IKDESCCMTE
400
EIFGPVTCVV
410
PFDSEEEVIE
420
RANNVKYGLA
430
ATVWSSNVGR
440
VHRVAKKLQS
450
GLVWTNCWLI
460
RELNLPFGGM
470
KSSGIGREGA
480
KDSYDFFTEI
KTITVKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0047102 | aminomuconate-semialdehyde dehydrogenase activity |
| Molecular Function | GO:0001758 | retinal dehydrogenase (NAD+) activity |
| Biological Process | GO:0097053 | L-kynurenine catabolic process |
| Biological Process | GO:0042574 | retinal metabolic process |
| Biological Process | GO:0042573 | retinoic acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.