Search Results

Overview

Uniprot IDQ9H2G2
Protein NameSTE20-like serine/threonine-protein kinase
Gene NameSLK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 FNFRKIFKLGSEKKK
1223 STQSRISKFYPIPSL
16 IFKLGSEKKKKQYEH
17 FKLGSEKKKKQYEHV
18 KLGSEKKKKQYEHVK
392 PTTDEPEKAVEDINE
681 KVTTQIDKEKKEIPV
683 TTQIDKEKKEIPVSI
775 SSFLSKTKDSGSISL

Function

Mediates apoptosis and actin stress fiber dissolution

Protein Sequence

10 MSFFNFRKIF 20 KLGSEKKKKQ 30 YEHVKRDLNP 40 EDFWEIIGEL 50 GDGAFGKVYK 60 AQNKETSVLA 70 AAKVIDTKSE 80 EELEDYMVEI 90 DILASCDHPN 100 IVKLLDAFYY 110 ENNLWILIEF 120 CAGGAVDAVM 130 LELERPLTES 140 QIQVVCKQTL 150 DALNYLHDNK 160 IIHRDLKAGN 170 ILFTLDGDIK 180 LADFGVSAKN 190 TRTIQRRDSF 200 IGTPYWMAPE 210 VVMCETSKDR 220 PYDYKADVWS 230 LGITLIEMAE 240 IEPPHHELNP 250 MRVLLKIAKS 260 EPPTLAQPSR 270 WSSNFKDFLK 280 KCLEKNVDAR 290 WTTSQLLQHP 300 FVTVDSNKPI 310 RELIAEAKAE 320 VTEEVEDGKE 330 EDEEEETENS 340 LPIPASKRAS 350 SDLSIASSEE 360 DKLSQNACIL 370 ESVSEKTERS 380 NSEDKLNSKI 390 LNEKPTTDEP 400 EKAVEDINEH 410 ITDAQLEAMT 420 ELHDRTAVIK 430 ENEREKRPKL 440 ENLPDTEDQE 450 TVDINSVSEG 460 KENNIMITLE 470 TNIEHNLKSE 480 EEKDQEKQQM 490 FENKLIKSEE 500 IKDTILQTVD 510 LVSQETGEKE 520 ANIQAVDSEV 530 GLTKEDTQEK 540 LGEDDKTQKD 550 VISNTSDVIG 560 TCEAADVAQK 570 VDEDSAEDTQ 580 SNDGKEVVEV 590 GQKLINKPMV 600 GPEAGGTKEV 610 PIKEIVEMNE 620 IEEGKNKEQA 630 INSSENIMDI 640 NEEPGTTEGE 650 EITESSSTEE 660 MEVRSVVADT 670 DQKALGSEVQ 680 DASKVTTQID 690 KEKKEIPVSI 700 KKEPEVTVVS 710 QPTEPQPVLI 720 PSININSDSG 730 ENKEEIGSLS 740 KTETILPPES 750 ENPKENDNDS 760 GTGSTADTSS 770 IDLNLSISSF 780 LSKTKDSGSI 790 SLQETRRQKK 800 TLKKTRKFIV 810 DGVEVSVTTS 820 KIVTDSDSKT 830 EELRFLRRQE 840 LRELRFLQKE 850 EQRAQQQLNS 860 KLQQQREQIF 870 RRFEQEMMSK 880 KRQYDQEIEN 890 LEKQQKQTIE 900 RLEQEHTNRL 910 RDEAKRIKGE 920 QEKELSKFQN 930 MLKNRKKEVI 940 NEVEKAPKEL 950 RKELMKRRKE 960 ELAQSQHAQE 970 QEFVQKQQQE 980 LDGSLKKIIQ 990 QQKAELANIE 1000 RECLNNKQQL 1010 MRAREAAIWE 1020 LEERHLQEKH 1030 QLLKQQLKDQ 1040 YFMQRHQLLK 1050 RHEKETEQMQ 1060 RYNQRLIEEL 1070 KNRQTQERAR 1080 LPKIQRSEAK 1090 TRMAMFKKSL 1100 RINSTATPDQ 1110 DRDKIKQFAA 1120 QEEKRQKNER 1130 MAQHQKHENQ 1140 MRDLQLQCEA 1150 NVRELHQLQN 1160 EKCHLLVEHE 1170 TQKLKELDEE 1180 HSQELKEWRE 1190 KLRPRKKTLE 1200 EEFARKLQEQ 1210 EVFFKMTGES 1220 ECLNPSTQSR 1230 ISKFYPIPSL HSTGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0051893 regulation of focal adhesion assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.