Search Results
Overview
| Uniprot ID | Q9H2J4 |
|---|---|
| Protein Name | Phosducin-like protein 3 |
| Gene Name | PDCL3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 83 | RRRLAEWKATKLKNK |
Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)
Protein Sequence
10
MQDPNADTEW
20
NDILRKKGIL
30
PPKESLKELE
40
EEAEEEQRIL
50
QQSVVKTYED
60
MTLEELEDHE
70
DEFNEEDERA
80
IEMYRRRRLA
90
EWKATKLKNK
100
FGEVLEISGK
110
DYVQEVTKAG
120
EGLWVILHLY
130
KQGIPLCALI
140
NQHLSGLARK
150
FPDVKFIKAI
160
STTCIPNYPD
170
RNLPTIFVYL
180
EGDIKAQFIG
190
PLVFGGMNLT
200
RDELEWKLSE
210
SGAIMTDLEE
220
NPKKPIEDVL
230
LSSVRRSVLM
KRDSDSEGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0097356 | perinucleolar compartment |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:1903333 | negative regulation of protein folding |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.