Overview
| Uniprot ID | Q9H2K2 |
|---|
| Protein Name | Poly [ADP-ribose] polymerase tankyrase-2 |
|---|
| Gene Name | TNKS2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 398 |
ANINEKTKEFLTPLH |
Function
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245)
Protein Sequence
10
MSGRRCAGGG
20
AACASAAAEA
30
VEPAARELFE
40
ACRNGDVERV
50
KRLVTPEKVN
60
SRDTAGRKST
70
PLHFAAGFGR
80
KDVVEYLLQN
90
GANVQARDDG
100
GLIPLHNACS
110
FGHAEVVNLL
120
LRHGADPNAR
130
DNWNYTPLHE
140
AAIKGKIDVC
150
IVLLQHGAEP
160
TIRNTDGRTA
170
LDLADPSAKA
180
VLTGEYKKDE
190
LLESARSGNE
200
EKMMALLTPL
210
NVNCHASDGR
220
KSTPLHLAAG
230
YNRVKIVQLL
240
LQHGADVHAK
250
DKGDLVPLHN
260
ACSYGHYEVT
270
ELLVKHGACV
280
NAMDLWQFTP
290
LHEAASKNRV
300
EVCSLLLSYG
310
ADPTLLNCHN
320
KSAIDLAPTP
330
QLKERLAYEF
340
KGHSLLQAAR
350
EADVTRIKKH
360
LSLEMVNFKH
370
PQTHETALHC
380
AAASPYPKRK
390
QICELLLRKG
400
ANINEKTKEF
410
LTPLHVASEK
420
AHNDVVEVVV
430
KHEAKVNALD
440
NLGQTSLHRA
450
AYCGHLQTCR
460
LLLSYGCDPN
470
IISLQGFTAL
480
QMGNENVQQL
490
LQEGISLGNS
500
EADRQLLEAA
510
KAGDVETVKK
520
LCTVQSVNCR
530
DIEGRQSTPL
540
HFAAGYNRVS
550
VVEYLLQHGA
560
DVHAKDKGGL
570
VPLHNACSYG
580
HYEVAELLVK
590
HGAVVNVADL
600
WKFTPLHEAA
610
AKGKYEICKL
620
LLQHGADPTK
630
KNRDGNTPLD
640
LVKDGDTDIQ
650
DLLRGDAALL
660
DAAKKGCLAR
670
VKKLSSPDNV
680
NCRDTQGRHS
690
TPLHLAAGYN
700
NLEVAEYLLQ
710
HGADVNAQDK
720
GGLIPLHNAA
730
SYGHVDVAAL
740
LIKYNACVNA
750
TDKWAFTPLH
760
EAAQKGRTQL
770
CALLLAHGAD
780
PTLKNQEGQT
790
PLDLVSADDV
800
SALLTAAMPP
810
SALPSCYKPQ
820
VLNGVRSPGA
830
TADALSSGPS
840
SPSSLSAASS
850
LDNLSGSFSE
860
LSSVVSSSGT
870
EGASSLEKKE
880
VPGVDFSITQ
890
FVRNLGLEHL
900
MDIFEREQIT
910
LDVLVEMGHK
920
ELKEIGINAY
930
GHRHKLIKGV
940
ERLISGQQGL
950
NPYLTLNTSG
960
SGTILIDLSP
970
DDKEFQSVEE
980
EMQSTVREHR
990
DGGHAGGIFN
1000
RYNILKIQKV
1010
CNKKLWERYT
1020
HRRKEVSEEN
1030
HNHANERMLF
1040
HGSPFVNAII
1050
HKGFDERHAY
1060
IGGMFGAGIY
1070
FAENSSKSNQ
1080
YVYGIGGGTG
1090
CPVHKDRSCY
1100
ICHRQLLFCR
1110
VTLGKSFLQF
1120
SAMKMAHSPP
1130
GHHSVTGRPS
1140
VNGLALAEYV
1150
IYRGEQAYPE
1160
YLITYQIMRP
EGMVDG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000242 |
pericentriolar material |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0003950 |
NAD+ poly-ADP-ribosyltransferase activity |
| Molecular Function |
GO:1990404 |
NAD+-protein mono-ADP-ribosyltransferase activity |
| Molecular Function |
GO:0140806 |
NAD+-protein-aspartate ADP-ribosyltransferase activity |
| Molecular Function |
GO:0140807 |
NAD+-protein-glutamate ADP-ribosyltransferase activity |
| Molecular Function |
GO:0016779 |
nucleotidyltransferase activity |
| Biological Process |
GO:1904357 |
negative regulation of telomere maintenance via telomere lengthening |
| Biological Process |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:1904355 |
positive regulation of telomere capping |
| Biological Process |
GO:0032212 |
positive regulation of telomere maintenance via telomerase |
| Biological Process |
GO:0070213 |
protein auto-ADP-ribosylation |
| Biological Process |
GO:0070198 |
protein localization to chromosome, telomeric region |
| Biological Process |
GO:0070212 |
protein poly-ADP-ribosylation |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.