Search Results
Overview
| Uniprot ID | Q9H2M3 |
|---|---|
| Protein Name | S-methylmethionine--homocysteine S-methyltransferase BHMT2 |
| Gene Name | BHMT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LAREVAGKGDALVAG |
| 120 | ICQTSIYKYQKDEAR |
| 198 | ECAVRLVKAGASIVG |
Function
Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor
Protein Sequence
10
MAPAGRPGAK
20
KGILERLESG
30
EVVIGDGSFL
40
ITLEKRGYVK
50
AGLWTPEAVI
60
EHPDAVRQLH
70
MEFLRAGSNV
80
MQTFTFSASE
90
DNMESKWEDV
100
NAAACDLARE
110
VAGKGDALVA
120
GGICQTSIYK
130
YQKDEARIKK
140
LFRQQLEVFA
150
WKNVDFLIAE
160
YFEHVEEAVW
170
AVEVLKESDR
180
PVAVTMCIGP
190
EGDMHDITPG
200
ECAVRLVKAG
210
ASIVGVNCRF
220
GPDTSLKTME
230
LMKEGLEWAG
240
LKAHLMVQPL
250
GFHAPDCGKE
260
GFVDLPEYPF
270
GLESRVATRW
280
DIQKYAREAY
290
NLGVRYIGGC
300
CGFEPYHIRA
310
IAEELAPERG
320
FLPPASEKHG
330
SWGSGLDMHT
340
KPWIRARARR
350
EYWENLLPAS
360
GRPFCPSLSK
PDF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0061627 | S-methylmethionine-homocysteine S-methyltransferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071267 | L-methionine salvage |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0046500 | S-adenosylmethionine metabolic process |
| Biological Process | GO:0033477 | S-methylmethionine metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.