Search Results
Overview
| Uniprot ID | Q9H2P9 |
|---|---|
| Protein Name | Diphthine methyl ester synthase |
| Gene Name | DPH5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | QSLENLIKGRKIYEP |
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis
Protein Sequence
10
MLYLIGLGLG
20
DAKDITVKGL
30
EVVRRCSRVY
40
LEAYTSVLTV
50
GKEALEEFYG
60
RKLVVADREE
70
VEQEADNILK
80
DADISDVAFL
90
VVGDPFGATT
100
HSDLVLRATK
110
LGIPYRVIHN
120
ASIMNAVGCC
130
GLQLYKFGET
140
VSIVFWTDTW
150
RPESFFDKVK
160
KNRQNGMHTL
170
CLLDIKVKEQ
180
SLENLIKGRK
190
IYEPPRYMSV
200
NQAAQQLLEI
210
VQNQRIRGEE
220
PAVTEETLCV
230
GLARVGADDQ
240
KIAAGTLRQM
250
CTVDLGEPLH
260
SLIITGGSIH
270
PMEMEMLSLF
280
SIPENSSESQ
SINGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0141133 | diphthine methyl ester synthase activity |
| Molecular Function | GO:0004164 | diphthine synthase activity |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0017183 | protein histidyl modification to diphthamide |
Reference
PMID: N/A