Search Results
Overview
| Uniprot ID | Q9H2U2 |
|---|---|
| Protein Name | Inorganic pyrophosphatase 2, mitochondrial |
| Gene Name | PPA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 224 | FHDIDDVKKFKPGYL |
| 247 | LYKVPDGKPENQFAF |
| 269 | AFALEVIKSTHQCWK |
| 276 | KSTHQCWKALLMKKC |
| 320 | SVSSSPNKESNEEEQ |
| 81 | EENGIPMKKARNDEY |
Function
Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598)
Protein Sequence
10
MSALLRLLRT
20
GAPAAACLRL
30
GTSAGTGSRR
40
AMALYHTEER
50
GQPCSQNYRL
60
FFKNVTGHYI
70
SPFHDIPLKV
80
NSKEENGIPM
90
KKARNDEYEN
100
LFNMIVEIPR
110
WTNAKMEIAT
120
KEPMNPIKQY
130
VKDGKLRYVA
140
NIFPYKGYIW
150
NYGTLPQTWE
160
DPHEKDKSTN
170
CFGDNDPIDV
180
CEIGSKILSC
190
GEVIHVKILG
200
ILALIDEGET
210
DWKLIAINAN
220
DPEASKFHDI
230
DDVKKFKPGY
240
LEATLNWFRL
250
YKVPDGKPEN
260
QFAFNGEFKN
270
KAFALEVIKS
280
THQCWKALLM
290
KKCNGGAINC
300
TNVQISDSPF
310
RCTQEEARSL
320
VESVSSSPNK
330
ESNEEEQVWH
FLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0004427 | inorganic diphosphate phosphatase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0071344 | diphosphate metabolic process |
| Biological Process | GO:0006796 | phosphate-containing compound metabolic process |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.