Search Results
Overview
| Uniprot ID | Q9H2X3 |
|---|---|
| Protein Name | C-type lectin domain family 4 member M |
| Gene Name | CLEC4M |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | YQELTQLKAAVGELP |
| 129 | AVGELPEKSKLQEIY |
Function
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates
Protein Sequence
10
MSDSKEPRVQ
20
QLGLLEEDPT
30
TSGIRLFPRD
40
FQFQQIHGHK
50
SSTGCLGHGA
60
LVLQLLSFML
70
LAGVLVAILV
80
QVSKVPSSLS
90
QEQSEQDAIY
100
QNLTQLKAAV
110
GELSEKSKLQ
120
EIYQELTQLK
130
AAVGELPEKS
140
KLQEIYQELT
150
RLKAAVGELP
160
EKSKLQEIYQ
170
ELTRLKAAVG
180
ELPEKSKLQE
190
IYQELTRLKA
200
AVGELPEKSK
210
LQEIYQELTE
220
LKAAVGELPE
230
KSKLQEIYQE
240
LTQLKAAVGE
250
LPDQSKQQQI
260
YQELTDLKTA
270
FERLCRHCPK
280
DWTFFQGNCY
290
FMSNSQRNWH
300
DSVTACQEVR
310
AQLVVIKTAE
320
EQNFLQLQTS
330
RSNRFSWMGL
340
SDLNQEGTWQ
350
WVDGSPLSPS
360
FQRYWNSGEP
370
NNSGNEDCAE
380
FSGSGWNDNR
390
CDVDNYWICK
KPAACFRDE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0043657 | host cell |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0005537 | D-mannose binding |
| Molecular Function | GO:0030369 | ICAM-3 receptor activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0038187 | pattern recognition receptor activity |
| Molecular Function | GO:0042605 | peptide antigen binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0046790 | virion binding |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0019882 | antigen processing and presentation |
| Biological Process | GO:0009988 | cell-cell recognition |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0075733 | intracellular transport of virus |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0046968 | peptide antigen transport |
| Biological Process | GO:0019065 | receptor-mediated endocytosis of virus by host cell |
| Biological Process | GO:0046813 | receptor-mediated virion attachment to host cell |
| Biological Process | GO:0046718 | symbiont entry into host cell |
| Biological Process | GO:0019079 | viral genome replication |
| Biological Process | GO:0019062 | virion attachment to host cell |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.