Search Results

Overview

Uniprot IDQ9H334
Protein NameForkhead box protein P1
Gene NameFOXP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
548 FQKRRPQKISGNPSL

Function

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735)

Protein Sequence

10 MMQESGTETK 20 SNGSAIQNGS 30 GGSNHLLECG 40 GLREGRSNGE 50 TPAVDIGAAD 60 LAHAQQQQQQ 70 ALQVARQLLL 80 QQQQQQQVSG 90 LKSPKRNDKQ 100 PALQVPVSVA 110 MMTPQVITPQ 120 QMQQILQQQV 130 LSPQQLQVLL 140 QQQQALMLQQ 150 QQLQEFYKKQ 160 QEQLQLQLLQ 170 QQHAGKQPKE 180 QQQVATQQLA 190 FQQQLLQMQQ 200 LQQQHLLSLQ 210 RQGLLTIQPG 220 QPALPLQPLA 230 QGMIPTELQQ 240 LWKEVTSAHT 250 AEETTGNNHS 260 SLDLTTTCVS 270 SSAPSKTSLI 280 MNPHASTNGQ 290 LSVHTPKRES 300 LSHEEHPHSH 310 PLYGHGVCKW 320 PGCEAVCEDF 330 QSFLKHLNSE 340 HALDDRSTAQ 350 CRVQMQVVQQ 360 LELQLAKDKE 370 RLQAMMTHLH 380 VKSTEPKAAP 390 QPLNLVSSVT 400 LSKSASEASP 410 QSLPHTPTTP 420 TAPLTPVTQG 430 PSVITTTSMH 440 TVGPIRRRYS 450 DKYNVPISSA 460 DIAQNQEFYK 470 NAEVRPPFTY 480 ASLIRQAILE 490 SPEKQLTLNE 500 IYNWFTRMFA 510 YFRRNAATWK 520 NAVRHNLSLH 530 KCFVRVENVK 540 GAVWTVDEVE 550 FQKRRPQKIS 560 GNPSLIKNMQ 570 SSHAYCTPLN 580 AALQASMAEN 590 SIPLYTTASM 600 GNPTLGNLAS 610 AIREELNGAM 620 EHTNSNESDS 630 SPGRSPMQAV 640 HPVHVKEEPL 650 DPEEAEGPLS 660 LVTTANHSPD 670 FDHDRDYEDE PVNEDME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001046 core promoter sequence-specific DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0050681 nuclear androgen receptor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042118 endothelial cell activation
Biological Process GO:0042116 macrophage activation
Biological Process GO:0042117 monocyte activation
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0002903 negative regulation of B cell apoptotic process
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0036035 osteoclast development
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0050861 positive regulation of B cell receptor signaling pathway
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
Biological Process GO:0032745 positive regulation of interleukin-21 production
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:1900424 regulation of defense response to bacterium
Biological Process GO:1901509 regulation of endothelial tube morphogenesis
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0032651 regulation of interleukin-1 beta production
Biological Process GO:0032655 regulation of interleukin-12 production
Biological Process GO:1901256 regulation of macrophage colony-stimulating factor production
Biological Process GO:0045655 regulation of monocyte differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032680 regulation of tumor necrosis factor production
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0033574 response to testosterone
Biological Process GO:0021756 striatum development
Biological Process GO:0061470 T follicular helper cell differentiation

Reference

PMID: N/A