Search Results
Overview
| Uniprot ID | Q9H361 |
|---|---|
| Protein Name | Polyadenylate-binding protein 3 |
| Gene Name | PABPC3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | EFPNVYIKNFGEDMD |
Function
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1
Protein Sequence
10
MNPSTPSYPT
20
ASLYVGDLHP
30
DVTEAMLYEK
40
FSPAGPILSI
50
RICRDLITSG
60
SSNYAYVNFQ
70
HTKDAEHALD
80
TMNFDVIKGK
90
PVRIMWSQRD
100
PSLRKSGVGN
110
IFVKNLDKSI
120
NNKALYDTVS
130
AFGNILSCNV
140
VCDENGSKGY
150
GFVHFETHEA
160
AERAIKKMNG
170
MLLNGRKVFV
180
GQFKSRKERE
190
AELGARAKEF
200
PNVYIKNFGE
210
DMDDERLKDL
220
FGKFGPALSV
230
KVMTDESGKS
240
KGFGFVSFER
250
HEDAQKAVDE
260
MNGKELNGKQ
270
IYVGRAQKKV
280
ERQTELKRTF
290
EQMKQDRITR
300
YQVVNLYVKN
310
LDDGIDDERL
320
RKAFSPFGTI
330
TSAKVMMEGG
340
RSKGFGFVCF
350
SSPEEATKAV
360
TEMNGRIVAT
370
KPLYVALAQR
380
KEERQAYLTN
390
EYMQRMASVR
400
AVPNQRAPPS
410
GYFMTAVPQT
420
QNHAAYYPPS
430
QIARLRPSPR
440
WTAQGARPHP
450
FQNKPSAIRP
460
GAPRVPFSTM
470
RPASSQVPRV
480
MSTQRVANTS
490
TQTVGPRPAA
500
AAAAAATPAV
510
RTVPRYKYAA
520
GVRNPQQHRN
530
AQPQVTMQQL
540
AVHVQGQETL
550
TASRLASAPP
560
QKQKQMLGER
570
LFPLIQAMHP
580
TLAGKITGML
590
LEIDNSELLY
600
MLESPESLRS
610
KVDEAVAVLQ
620
AHQAKEATQK
630
AVNSATGVPT
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0008143 | poly(A) binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Biological Process | GO:0016071 | mRNA metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.