Search Results
Overview
| Uniprot ID | Q9H3K6 |
|---|---|
| Protein Name | BolA-like protein 2 |
| Gene Name | BOLA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | VSAKFEGKPLLQRHR |
Function
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415)
Protein Sequence
10
MELSAEYLRE
20
KLQRDLEAEH
30
VEVEDTTLNR
40
CSCSFRVLVV
50
SAKFEGKPLL
60
QRHRLVNACL
70
AEELPHIHAF
80
EQKTLTPDQW
ARERQK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.