Search Results
Overview
| Uniprot ID | Q9H3M9 |
|---|---|
| Protein Name | Ataxin-3-like protein |
| Gene Name | ATXN3L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 206 | QKEHRVYKTVLEKVS |
Function
Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro) (PubMed:21118805). Acts as a deubiquitinating enzyme for the transcription factor KLF5, playing a role in the regulation of KLF5 stability (PubMed:26079537)
Protein Sequence
10
MDFIFHEKQE
20
GFLCAQHCLN
30
NLLQGEYFSP
40
VELASIAHQL
50
DEEERMRMAE
60
GGVTSEEYLA
70
FLQQPSENMD
80
DTGFFSIQVI
90
SNALKFWGLE
100
IIHFNNPEYQ
110
KLGIDPINER
120
SFICNYKQHW
130
FTIRKFGKHW
140
FNLNSLLAGP
150
ELISDTCLAN
160
FLARLQQQAY
170
SVFVVKGDLP
180
DCEADQLLQI
190
ISVEEMDTPK
200
LNGKKLVKQK
210
EHRVYKTVLE
220
KVSEESDESG
230
TSDQDEEDFQ
240
RALELSRQET
250
NREDEHLRST
260
IELSMQGSSG
270
NTSQDLPKTS
280
CVTPASEQPK
290
KIKEDYFEKH
300
QQEQKQQQQQ
310
SDLPGHSSYL
320
HERPTTSSRA
330
IESDLSDDIS
340
EGTVQAAVDT
350
ILEIMRKNLK
IKGEK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:1904262 | negative regulation of TORC1 signaling |
| Biological Process | GO:1904294 | positive regulation of ERAD pathway |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.