Overview
| Uniprot ID | Q9H3N1 |
|---|
| Protein Name | Thioredoxin-related transmembrane protein 1 |
|---|
| Gene Name | TMX1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 223 |
PYPYPSKKLLSESAQ |
| 233 |
SESAQPLKKVEEEQE |
| 234 |
ESAQPLKKVEEEQEA |
Function
Thioredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (PubMed:27502484)
Protein Sequence
10
MAPSGSLAVP
20
LAVLVLLLWG
30
APWTHGRRSN
40
VRVITDENWR
50
ELLEGDWMIE
60
FYAPWCPACQ
70
NLQPEWESFA
80
EWGEDLEVNI
90
AKVDVTEQPG
100
LSGRFIITAL
110
PTIYHCKDGE
120
FRRYQGPRTK
130
KDFINFISDK
140
EWKSIEPVSS
150
WFGPGSVLMS
160
SMSALFQLSM
170
WIRTCHNYFI
180
EDLGLPVWGS
190
YTVFALATLF
200
SGLLLGLCMI
210
FVADCLCPSK
220
RRRPQPYPYP
230
SKKLLSESAQ
240
PLKKVEEEQE
250
ADEEDVSEEE
260
AESKEGTNKD
270
FPQNAIRQRS
280
LGPSLATDKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005730 |
nucleolus |
| Molecular Function |
GO:0015036 |
disulfide oxidoreductase activity |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0003756 |
protein disulfide isomerase activity |
| Molecular Function |
GO:0015035 |
protein-disulfide reductase activity |
| Biological Process |
GO:0090331 |
negative regulation of platelet aggregation |
| Biological Process |
GO:0010868 |
negative regulation of triglyceride biosynthetic process |
| Biological Process |
GO:1904294 |
positive regulation of ERAD pathway |
| Biological Process |
GO:0051924 |
regulation of calcium ion transport |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.