Search Results

Overview

Uniprot ID	Q9H3S7
Protein Name	Tyrosine-protein phosphatase non-receptor type 23
Gene Name	PTPN23
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
288	NEAIKLAKGQPDTVQ

Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563)

Protein Sequence

10 MEAVPRMPMI 20 WLDLKEAGDF 30 HFQPAVKKFV 40 LKNYGENPEA 50 YNEELKKLEL 60 LRQNAVRVPR 70 DFEGCSVLRK 80 YLGQLHYLQS 90 RVPMGSGQEA 100 AVPVTWTEIF 110 SGKSVAHEDI 120 KYEQACILYN 130 LGALHSMLGA 140 MDKRVSEEGM 150 KVSCTHFQCA 160 AGAFAYLREH 170 FPQAYSVDMS 180 RQILTLNVNL 190 MLGQAQECLL 200 EKSMLDNRKS 210 FLVARISAQV 220 VDYYKEACRA 230 LENPDTASLL 240 GRIQKDWKKL 250 VQMKIYYFAA 260 VAHLHMGKQA 270 EEQQKFGERV 280 AYFQSALDKL 290 NEAIKLAKGQ 300 PDTVQDALRF 310 TMDVIGGKYN 320 SAKKDNDFIY 330 HEAVPALDTL 340 QPVKGAPLVK 350 PLPVNPTDPA 360 VTGPDIFAKL 370 VPMAAHEASS 380 LYSEEKAKLL 390 REMMAKIEDK 400 NEVLDQFMDS 410 MQLDPETVDN 420 LDAYSHIPPQ 430 LMEKCAALSV 440 RPDTVRNLVQ 450 SMQVLSGVFT 460 DVEASLKDIR 470 DLLEEDELLE 480 QKFQEAVGQA 490 GAISITSKAE 500 LAEVRREWAK 510 YMEVHEKASF 520 TNSELHRAMN 530 LHVGNLRLLS 540 GPLDQVRAAL 550 PTPALSPEDK 560 AVLQNLKRIL 570 AKVQEMRDQR 580 VSLEQQLREL 590 IQKDDITASL 600 VTTDHSEMKK 610 LFEEQLKKYD 620 QLKVYLEQNL 630 AAQDRVLCAL 640 TEANVQYAAV 650 RRVLSDLDQK 660 WNSTLQTLVA 670 SYEAYEDLMK 680 KSQEGRDFYA 690 DLESKVAALL 700 ERTQSTCQAR 710 EAARQQLLDR 720 ELKKKPPPRP 730 TAPKPLLPRR 740 EESEAVEAGD 750 PPEELRSLPP 760 DMVAGPRLPD 770 TFLGSATPLH 780 FPPSPFPSST 790 GPGPHYLSGP 800 LPPGTYSGPT 810 QLIQPRAPGP 820 HAMPVAPGPA 830 LYPAPAYTPE 840 LGLVPRSSPQ 850 HGVVSSPYVG 860 VGPAPPVAGL 870 PSAPPPQFSG 880 PELAMAVRPA 890 TTTVDSIQAP 900 IPSHTAPRPN 910 PTPAPPPPCF 920 PVPPPQPLPT 930 PYTYPAGAKQ 940 PIPAQHHFSS 950 GIPAGFPAPR 960 IGPQPQPHPQ 970 PHPSQAFGPQ 980 PPQQPLPLQH 990 PHLFPPQAPG 1000 LLPPQSPYPY 1010 APQPGVLGQP 1020 PPPLHTQLYP 1030 GPAQDPLPAH 1040 SGALPFPSPG 1050 PPQPPHPPLA 1060 YGPAPSTRPM 1070 GPQAAPLTIR 1080 GPSSAGQSTP 1090 SPHLVPSPAP 1100 SPGPGPVPPR 1110 PPAAEPPPCL 1120 RRGAAAADLL 1130 SSSPESQHGG 1140 TQSPGGGQPL 1150 LQPTKVDAAE 1160 GRRPQALRLI 1170 ERDPYEHPER 1180 LRQLQQELEA 1190 FRGQLGDVGA 1200 LDTVWRELQD 1210 AQEHDARGRS 1220 IAIARCYSLK 1230 NRHQDVMPYD 1240 SNRVVLRSGK 1250 DDYINASCVE 1260 GLSPYCPPLV 1270 ATQAPLPGTA 1280 ADFWLMVHEQ 1290 KVSVIVMLVS 1300 EAEMEKQKVA 1310 RYFPTERGQP 1320 MVHGALSLAL 1330 SSVRSTETHV 1340 ERVLSLQFRD 1350 QSLKRSLVHL 1360 HFPTWPELGL 1370 PDSPSNLLRF 1380 IQEVHAHYLH 1390 QRPLHTPIIV 1400 HCSSGVGRTG 1410 AFALLYAAVQ 1420 EVEAGNGIPE 1430 LPQLVRRMRQ 1440 QRKHMLQEKL 1450 HLRFCYEAVV 1460 RHVEQVLQRH 1470 GVPPPCKPLA 1480 SASISQKNHL 1490 PQDSQDLVLG 1500 GDVPISSIQA 1510 TIAKLSIRPP 1520 GGLESPVASL 1530 PGPAEPPGLP 1540 PASLPESTPI 1550 PSSSPPPLSS 1560 PLPEAPQPKE 1570 EPPVPEAPSS 1580 GPPSSSLELL 1590 ASLTPEAFSL 1600 DSSLRGKQRM 1610 SKHNFLQAHN 1620 GQGLRATRPS 1630 DDPLSLLDPL WTLNKT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0036064	ciliary basal body
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0004725	protein tyrosine phosphatase activity
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0045022	early endosome to late endosome transport
Biological Process	GO:0032456	endocytic recycling
Biological Process	GO:0010633	negative regulation of epithelial cell migration
Biological Process	GO:1903393	positive regulation of adherens junction organization
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport
Biological Process	GO:1903387	positive regulation of homophilic cell adhesion
Biological Process	GO:0061357	positive regulation of Wnt protein secretion
Biological Process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.