Search Results
Overview
| Uniprot ID | Q9H444 |
|---|---|
| Protein Name | Charged multivesicular body protein 4b |
| Gene Name | CHMP4B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | NTNTEVLKNMGYAAK |
| 114 | KNMGYAAKAMKAAHD |
| 117 | GYAAKAMKAAHDNMD |
| 14 | LFGAGGGKAGKGGPT |
| 17 | AGGGKAGKGGPTPQE |
| 205 | ALPSKPAKKKEEEDD |
| 6 | **MSVFGKLFGAGGG |
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904930 | amphisome membrane |
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0000815 | ESCRT III complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005828 | kinetochore microtubule |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0030117 | membrane coat |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0032585 | multivesicular body membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0097352 | autophagosome maturation |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0010458 | exit from mitosis |
| Biological Process | GO:1902774 | late endosome to lysosome transport |
| Biological Process | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0036438 | maintenance of lens transparency |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0061952 | midbody abscission |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:0061763 | multivesicular body-lysosome fusion |
| Biological Process | GO:0050877 | nervous system process |
| Biological Process | GO:0031468 | nuclear membrane reassembly |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:0006620 | post-translational protein targeting to endoplasmic reticulum membrane |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:1901673 | regulation of mitotic spindle assembly |
| Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0006900 | vesicle budding from membrane |
| Biological Process | GO:0051469 | vesicle fusion with vacuole |
| Biological Process | GO:0046755 | viral budding |
| Biological Process | GO:0046761 | viral budding from plasma membrane |
| Biological Process | GO:0039702 | viral budding via host ESCRT complex |
Reference
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