Search Results
Overview
| Uniprot ID | Q9H467 |
|---|---|
| Protein Name | CUE domain-containing protein 2 |
| Gene Name | CUEDC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 256 | DNQVVSTKGERFKDV |
Function
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism
Protein Sequence
10
MELERIVSAA
20
LLAFVQTHLP
30
EADLSGLDEV
40
IFSYVLGVLE
50
DLGPSGPSEE
60
NFDMEAFTEM
70
MEAYVPGFAH
80
IPRGTIGDMM
90
QKLSGQLSDA
100
RNKENLQPQS
110
SGVQGQVPIS
120
PEPLQRPEML
130
KEETRSSAAA
140
AADTQDEATG
150
AEEELLPGVD
160
VLLEVFPTCS
170
VEQAQWVLAK
180
ARGDLEEAVQ
190
MLVEGKEEGP
200
AAWEGPNQDL
210
PRRLRGPQKD
220
ELKSFILQKY
230
MMVDSAEDQK
240
IHRPMAPKEA
250
PKKLIRYIDN
260
QVVSTKGERF
270
KDVRNPEAEE
280
MKATYINLKP
ARKYRFH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:0010936 | negative regulation of macrophage cytokine production |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.