Search Results

Overview

Uniprot IDQ9H4A4
Protein NameAminopeptidase B
Gene NameRNPEP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
260 PCLIDAAKEEYNGVI
446 KAYVHEFKFRSILAD
592 QEDFWKVKEFLHNQG
600 EFLHNQGKQKYTLPL

Function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)

Protein Sequence

10 MASGEHSPGS 20 GAARRPLHSA 30 QAVDVASASN 40 FRAFELLHLH 50 LDLRAEFGPP 60 GPGAGSRGLS 70 GTAVLDLRCL 80 EPEGAAELRL 90 DSHPCLEVTA 100 AALRRERPGS 110 EEPPAEPVSF 120 YTQPFSHYGQ 130 ALCVSFPQPC 140 RAAERLQVLL 150 TYRVGEGPGV 160 CWLAPEQTAG 170 KKKPFVYTQG 180 QAVLNRAFFP 190 CFDTPAVKYK 200 YSALIEVPDG 210 FTAVMSASTW 220 EKRGPNKFFF 230 QMCQPIPSYL 240 IALAIGDLVS 250 AEVGPRSRVW 260 AEPCLIDAAK 270 EEYNGVIEEF 280 LATGEKLFGP 290 YVWGRYDLLF 300 MPPSFPFGGM 310 ENPCLTFVTP 320 CLLAGDRSLA 330 DVIIHEISHS 340 WFGNLVTNAN 350 WGEFWLNEGF 360 TMYAQRRIST 370 ILFGAAYTCL 380 EAATGRALLR 390 QHMDITGEEN 400 PLNKLRVKIE 410 PGVDPDDTYN 420 ETPYEKGFCF 430 VSYLAHLVGD 440 QDQFDSFLKA 450 YVHEFKFRSI 460 LADDFLDFYL 470 EYFPELKKKR 480 VDIIPGFEFD 490 RWLNTPGWPP 500 YLPDLSPGDS 510 LMKPAEELAQ 520 LWAAEELDMK 530 AIEAVAISPW 540 KTYQLVYFLD 550 KILQKSPLPP 560 GNVKKLGDTY 570 PSISNARNAE 580 LRLRWGQIVL 590 KNDHQEDFWK 600 VKEFLHNQGK 610 QKYTLPLYHA 620 MMGGSEVAQT 630 LAKETFASTA 640 SQLHSNVVNY 650 VQQIVAPKGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0004301 epoxide hydrolase activity
Molecular Function GO:0070006 metalloaminopeptidase activity
Molecular Function GO:0008235 metalloexopeptidase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006508 proteolysis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.