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Overview

Uniprot IDQ9H4A5
Protein NameGolgi phosphoprotein 3-like
Gene NameGOLPH3L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
15 ARRTEISKNSEKKME

Function

Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane

Protein Sequence

10 MTTLTHRARR 20 TEISKNSEKK 30 MESEEDSNWE 40 KSPDNEDSGD 50 SKDIRLTLME 60 EVLLLGLKDK 70 EGYTSFWNDC 80 ISSGLRGGIL 90 IELAMRGRIY 100 LEPPTMRKKR 110 LLDRKVLLKS 120 DSPTGDVLLD 130 ETLKHIKATE 140 PTETVQTWIE 150 LLTGETWNPF 160 KLQYQLRNVR 170 ERIAKNLVEK 180 GILTTEKQNF 190 LLFDMTTHPV 200 TNTTEKQRLV 210 KKLQDSVLER 220 WVNDPQRMDK 230 RTLALLVLAH 240 SSDVLENVFS 250 SLTDDKYDVA 260 MNRAKDLVEL 270 DPEVEGTKPS 280 ATEMIWAVLA AFNKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0031985 Golgi cisterna
Cellular Component GO:0032580 Golgi cisterna membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005802 trans-Golgi network
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0140312 cargo adaptor activity
Molecular Function GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process GO:0007030 Golgi organization
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0048194 Golgi vesicle budding
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0140450 protein targeting to Golgi apparatus
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.