Search Results

Overview

Uniprot IDQ9H4A6
Protein NameGolgi phosphoprotein 3
Gene NameGOLPH3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
224 VQEAVLDKWVNDPHR

Function

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis

Protein Sequence

10 MTSLTQRSSG 20 LVQRRTEASR 30 NAADKERAAG 40 GGAGSSEDDA 50 QSRRDEQDDD 60 DKGDSKETRL 70 TLMEEVLLLG 80 LKDREGYTSF 90 WNDCISSGLR 100 GCMLIELALR 110 GRLQLEACGM 120 RRKSLLTRKV 130 ICKSDAPTGD 140 VLLDEALKHV 150 KETQPPETVQ 160 NWIELLSGET 170 WNPLKLHYQL 180 RNVRERLAKN 190 LVEKGVLTTE 200 KQNFLLFDMT 210 THPLTNNNIK 220 QRLIKKVQEA 230 VLDKWVNDPH 240 RMDRRLLALI 250 YLAHASDVLE 260 NAFAPLLDEQ 270 YDLATKRVRQ 280 LLDLDPEVEC 290 LKANTNEVLW AVVAAFTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0031985 Golgi cisterna
Cellular Component GO:0032580 Golgi cisterna membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0140312 cargo adaptor activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process GO:0090164 asymmetric Golgi ribbon formation
Biological Process GO:0060352 cell adhesion molecule production
Biological Process GO:0016477 cell migration
Biological Process GO:0072752 cellular response to rapamycin
Biological Process GO:0010467 gene expression
Biological Process GO:0009101 glycoprotein biosynthetic process
Biological Process GO:0007030 Golgi organization
Biological Process GO:0090161 Golgi ribbon formation
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0048194 Golgi vesicle budding
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0050901 leukocyte tethering or rolling
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0032008 positive regulation of TOR signaling
Biological Process GO:0045053 protein retention in Golgi apparatus
Biological Process GO:0009306 protein secretion
Biological Process GO:0140450 protein targeting to Golgi apparatus
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.