Search Results

Overview

Uniprot IDQ9H4G0
Protein NameBand 4.1-like protein 1
Gene NameEPB41L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 EYECEVEKHGRGQVL
493 QETTPRHKQEFLDKP
524 TLKEPNSKLIHRDRD
548 SPASPSPKGTPEKAN
595 ERDTVFLKDNHLAIE
710 SSLAIRKKIEPEAVL
764 ENSLKSGKGAAAMIP
789 SLSPIIGKDVLTSTY
816 THVTKTVKGGFSETR
850 ALAIKEAKLQHPDML
860 HPDMLVTKAVVYRET
95 QKIAKKYKSAICRVT

Function

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases

Protein Sequence

10 MTTETGPDSE 20 VKKAQEEAPQ 30 QPEAAAAVTT 40 PVTPAGHGHP 50 EANSNEKHPS 60 QQDTRPAEQS 70 LDMEEKDYSE 80 ADGLSERTTP 90 SKAQKSPQKI 100 AKKYKSAICR 110 VTLLDASEYE 120 CEVEKHGRGQ 130 VLFDLVCEHL 140 NLLEKDYFGL 150 TFCDADSQKN 160 WLDPSKEIKK 170 QIRSSPWNFA 180 FTVKFYPPDP 190 AQLTEDITRY 200 YLCLQLRADI 210 ITGRLPCSFV 220 THALLGSYAV 230 QAELGDYDAE 240 EHVGNYVSEL 250 RFAPNQTREL 260 EERIMELHKT 270 YRGMTPGEAE 280 IHFLENAKKL 290 SMYGVDLHHA 300 KDSEGIDIML 310 GVCANGLLIY 320 RDRLRINRFA 330 WPKILKISYK 340 RSNFYIKIRP 350 GEYEQFESTI 360 GFKLPNHRSA 370 KRLWKVCIEH 380 HTFFRLVSPE 390 PPPKGFLVMG 400 SKFRYSGRTQ 410 AQTRQASALI 420 DRPAPFFERS 430 SSKRYTMSRS 440 LDGAEFSRPA 450 SVSENHDAGP 460 DGDKRDEDGE 470 SGGQRSEAEE 480 GEVRTPTKIK 490 ELKPEQETTP 500 RHKQEFLDKP 510 EDVLLKHQAS 520 INELKRTLKE 530 PNSKLIHRDR 540 DWERERRLPS 550 SPASPSPKGT 560 PEKANERAGL 570 REGSEEKVKP 580 PRPRAPESDT 590 GDEDQDQERD 600 TVFLKDNHLA 610 IERKCSSITV 620 SSTSSLEAEV 630 DFTVIGDYHG 640 SAFEDFSRSL 650 PELDRDKSDS 660 DTEGLLFSRD 670 LNKGAPSQDD 680 ESGGIEDSPD 690 RGACSTPDMP 700 QFEPVKTETM 710 TVSSLAIRKK 720 IEPEAVLQTR 730 VSAMDNTQQV 740 DGSASVGREF 750 IATTPSITTE 760 TISTTMENSL 770 KSGKGAAAMI 780 PGPQTVATEI 790 RSLSPIIGKD 800 VLTSTYGATA 810 ETLSTSTTTH 820 VTKTVKGGFS 830 ETRIEKRIII 840 TGDEDVDQDQ 850 ALALAIKEAK 860 LQHPDMLVTK 870 AVVYRETDPS 880 PEERDKKPQE S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.