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Overview

Uniprot IDQ9H4I2
Protein NameZinc fingers and homeoboxes protein 3
Gene NameZHX3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
188 ITKTPIMKIMKGKAE
510 HEQLSALKGSFCRNQ
730 SPIKINLKNLRVTEA

Function

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA

Protein Sequence

10 MASKRKSTTP 20 CMIPVKTVVL 30 QDASMEAQPA 40 ETLPEGPQQD 50 LPPEASAASS 60 EAAQNPSSTD 70 GSTLANGHRS 80 TLDGYLYSCK 90 YCDFRSHDMT 100 QFVGHMNSEH 110 TDFNKDPTFV 120 CSGCSFLAKT 130 PEGLSLHNAT 140 CHSGEASFVW 150 NVAKPDNHVV 160 VEQSIPESTS 170 TPDLAGEPSA 180 EGADGQAEII 190 ITKTPIMKIM 200 KGKAEAKKIH 210 TLKENVPSQP 220 VGEALPKLST 230 GEMEVREGDH 240 SFINGAVPVS 250 QASASSAKNP 260 HAANGPLIGT 270 VPVLPAGIAQ 280 FLSLQQQPPV 290 HAQHHVHQPL 300 PTAKALPKVM 310 IPLSSIPTYN 320 AAMDSNSFLK 330 NSFHKFPYPT 340 KAELCYLTVV 350 TKYPEEQLKI 360 WFTAQRLKQG 370 ISWSPEEIED 380 ARKKMFNTVI 390 QSVPQPTITV 400 LNTPLVASAG 410 NVQHLIQAAL 420 PGHVVGQPEG 430 TGGGLLVTQP 440 LMANGLQATS 450 SPLPLTVTSV 460 PKQPGVAPIN 470 TVCSNTTSAV 480 KVVNAAQSLL 490 TACPSITSQA 500 FLDASIYKNK 510 KSHEQLSALK 520 GSFCRNQFPG 530 QSEVEHLTKV 540 TGLSTREVRK 550 WFSDRRYHCR 560 NLKGSRAMIP 570 GDHSSIIIDS 580 VPEVSFSPSS 590 KVPEVTCIPT 600 TATLATHPSA 610 KRQSWHQTPD 620 FTPTKYKERA 630 PEQLRALESS 640 FAQNPLPLDE 650 ELDRLRSETK 660 MTRREIDSWF 670 SERRKKVNAE 680 ETKKAEENAS 690 QEEEEAAEDE 700 GGEEDLASEL 710 RVSGENGSLE 720 MPSSHILAER 730 KVSPIKINLK 740 NLRVTEANGR 750 NEIPGLGACD 760 PEDDESNKLA 770 EQLPGKVSCK 780 KTAQQRHLLR 790 QLFVQTQWPS 800 NQDYDSIMAQ 810 TGLPRPEVVR 820 WFGDSRYALK 830 NGQLKWYEDY 840 KRGNFPPGLL 850 VIAPGNRELL 860 QDYYMTHKML 870 YEEDLQNLCD 880 KTQMSSQQVK 890 QWFAEKMGEE 900 TRAVADTGSE 910 DQGPGTGELT 920 AVHKGMGDTY 930 SEVSENSESW 940 EPRVPEASSE 950 PFDTSSPQAG RQLETD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0046982 protein heterodimerization activity
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.