Overview
| Uniprot ID | Q9H4M9 |
|---|
| Protein Name | EH domain-containing protein 1 |
|---|
| Gene Name | EHD1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
DPRRPFRKLNAFGNA |
| 293 |
PRNAALRKLNDLIKR |
| 315 |
AYIISSLKKEMPNVF |
| 316 |
YIISSLKKEMPNVFG |
| 327 |
NVFGKESKKKELVNN |
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250)
Protein Sequence
10
MFSWVSKDAR
20
RKKEPELFQT
30
VAEGLRQLYA
40
QKLLPLEEHY
50
RFHEFHSPAL
60
EDADFDNKPM
70
VLLVGQYSTG
80
KTTFIRHLIE
90
QDFPGMRIGP
100
EPTTDSFIAV
110
MHGPTEGVVP
120
GNALVVDPRR
130
PFRKLNAFGN
140
AFLNRFMCAQ
150
LPNPVLDSIS
160
IIDTPGILSG
170
EKQRISRGYD
180
FAAVLEWFAE
190
RVDRIILLFD
200
AHKLDISDEF
210
SEVIKALKNH
220
EDKIRVVLNK
230
ADQIETQQLM
240
RVYGALMWSL
250
GKIINTPEVV
260
RVYIGSFWSH
270
PLLIPDNRKL
280
FEAEEQDLFK
290
DIQSLPRNAA
300
LRKLNDLIKR
310
ARLAKVHAYI
320
ISSLKKEMPN
330
VFGKESKKKE
340
LVNNLGEIYQ
350
KIEREHQISP
360
GDFPSLRKMQ
370
ELLQTQDFSK
380
FQALKPKLLD
390
TVDDMLANDI
400
ARLMVMVRQE
410
ESLMPSQVVK
420
GGAFDGTMNG
430
PFGHGYGEGA
440
GEGIDDVEWV
450
VGKDKPTYDE
460
IFYTLSPVNG
470
KITGANAKKE
480
MVKSKLPNTV
490
LGKIWKLADV
500
DKDGLLDDEE
510
FALANHLIKV
520
KLEGHELPAD
530
LPPHLVPPSK
RRHE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0020018 |
ciliary pocket membrane |
| Cellular Component |
GO:0048786 |
presynaptic active zone |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:1990090 |
cellular response to nerve growth factor stimulus |
| Biological Process |
GO:0042632 |
cholesterol homeostasis |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0034383 |
low-density lipoprotein particle clearance |
| Biological Process |
GO:0031175 |
neuron projection development |
| Biological Process |
GO:0010886 |
positive regulation of cholesterol storage |
| Biological Process |
GO:2001137 |
positive regulation of endocytic recycling |
| Biological Process |
GO:1901741 |
positive regulation of myoblast fusion |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0061512 |
protein localization to cilium |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Cellular Component |
GO:0035869 |
ciliary transition zone |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0030139 |
endocytic vesicle |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0031095 |
platelet dense tubular network membrane |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.