Search Results

Overview

Uniprot IDQ9H501
Protein NameESF1 homolog
Gene NameESF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
138 LDNSIGIKKMKTSCK
139 DNSIGIKKMKTSCKF
147 MKTSCKFKIDSNISP
170 QKNKKEKKNIVQHTT
197 SGTSEIVKSPRIECS
46 RAMFHDKKFKLNYAV
48 MFHDKKFKLNYAVDK
55 KLNYAVDKRGRPISH
581 DDEEQIAKYRQLLQV
683 VKQIGINKKSVKSAK
684 KQIGINKKSVKSAKD
727 KKHFNYNKIVEHQNL
736 VEHQNLSKKKKKQLM
737 EHQNLSKKKKKQLMK
738 HQNLSKKKKKQLMKK

Function

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)

Protein Sequence

10 MSSKQEIMSD 20 QRFRRVAKDP 30 RFWEMPEKDR 40 KVKIDKRFRA 50 MFHDKKFKLN 60 YAVDKRGRPI 70 SHSTTEDLKR 80 FYDLSDSDSN 90 LSGEDSKALS 100 QKKIKKKKTQ 110 TKKEIDSKNL 120 VEKKKETKKA 130 NHKGSENKTD 140 LDNSIGIKKM 150 KTSCKFKIDS 160 NISPKKDSKE 170 FTQKNKKEKK 180 NIVQHTTDSS 190 LEEKQRTLDS 200 GTSEIVKSPR 210 IECSKTRREM 220 QSVVQLIMTR 230 DSDGYENSTD 240 GEMCDKDALE 250 EDSESVSEIG 260 SDEESENEIT 270 SVGRASGDDD 280 GSEDDEEEDE 290 DEEEDEDEDS 300 EDDDKSDSGP 310 DLARGKGNIE 320 TSSEDEDDTA 330 DLFPEESGFE 340 HAWRELDKDA 350 PRADEITRRL 360 AVCNMDWDRL 370 KAKDLLALFN 380 SFKPKGGVIF 390 SVKIYPSEFG 400 KERMKEEQVQ 410 GPVELLSIPE 420 DAPEKDWTSR 430 EKLRDYQFKR 440 LKYYYAVVDC 450 DSPETASKIY 460 EDCDGLEFES 470 SCSFIDLRFI 480 PDDITFDDEP 490 KDVASEVNLT 500 AYKPKYFTSA 510 AMGTSTVEIT 520 WDETDHERIT 530 MLNRKFKKEE 540 LLDMDFQAYL 550 ASSSEDEEEI 560 EEELQGDDGV 570 NVEEDGKTKK 580 SQKDDEEQIA 590 KYRQLLQVIQ 600 EKEKKGKEND 610 MEMEIKWVPG 620 LKESAEEMVK 630 NKLEGKDKLT 640 PWEQFLEKKK 650 EKKRLKRKQK 660 ALAEEASEEE 670 LPSDVDLNDP 680 YFAEEVKQIG 690 INKKSVKSAK 700 DGTSPEEEIE 710 IERQKAEMAL 720 LMMDEDEDSK 730 KHFNYNKIVE 740 HQNLSKKKKK 750 QLMKKKELIE 760 DDFEVNVNDA 770 RFQAMYTSHL 780 FNLDPSDPNF 790 KKTKAMEKIL 800 EEKARQRERK 810 EQELTQAIKK 820 KESEIEKESQ 830 RKSIDPALSM 840 LIKSIKTKTE 850 QFQARKKQKV K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006364 rRNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.