Search Results

Overview

Uniprot ID	Q9H583
Protein Name	HEAT repeat-containing protein 1
Gene Name	HEATR1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1180	PLGTVQQKRRQKMQQ
1189	RQKMQQKKSQDLESV
1483	EKEETIPKAVSFNKS
435	LIRLLESKYPRTLDV

Function

Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354)

Protein Sequence

10 MTSLAQQLQR 20 LALPQSDASL 30 LSRDEVASLL 40 FDPKEAATID 50 RDTAFAIGCT 60 GLEELLGIDP 70 SFEQFEAPLF 80 SQLAKTLERS 90 VQTKAVNKQL 100 DENISLFLIH 110 LSPYFLLKPA 120 QKCLEWLIHR 130 FHIHLYNQDS 140 LIACVLPYHE 150 TRIFVRVIQL 160 LKINNSKHRW 170 FWLLPVKQSG 180 VPLAKGTLIT 190 HCYKDLGFMD 200 FICSLVTKSV 210 KVFAEYPGSS 220 AQLRVLLAFY 230 ASTIVSALVA 240 AEDVSDNIIA 250 KLFPYIQKGL 260 KSSLPDYRAA 270 TYMIICQISV 280 KVTMENTFVN 290 SLASQIIKTL 300 TKIPSLIKDG 310 LSCLIVLLQR 320 QKPESLGKKP 330 FPHLCNVPDL 340 ITILHGISET 350 YDVSPLLHYM 360 LPHLVVSIIH 370 HVTGEETEGM 380 DGQIYKRHLE 390 AILTKISLKN 400 NLDHLLASLL 410 FEEYISYSSQ 420 EEMDSNKVSL 430 LNEQFLPLIR 440 LLESKYPRTL 450 DVVLEEHLKE 460 IADLKKQELF 470 HQFVSLSTSG 480 GKYQFLADSD 490 TSLMLSLNHP 500 LAPVRILAMN 510 HLKKIMKTSK 520 EGVDESFIKE 530 AVLARLGDDN 540 IDVVLSAISA 550 FEIFKEHFSS 560 EVTISNLLNL 570 FQRAELSKNG 580 EWYEVLKIAA 590 DILIKEEILS 600 ENDQLSNQVV 610 VCLLPFMVIN 620 NDDTESAEMK 630 IAIYLSKSGI 640 CSLHPLLRGW 650 EEALENVIKS 660 TKPGKLIGVA 670 NQKMIELLAD 680 NINLGDPSSM 690 LKMVEDLISV 700 GEEESFNLKQ 710 KVTFHVILSV 720 LVSCCSSLKE 730 THFPFAIRVF 740 SLLQKKIKKL 750 ESVITAVEIP 760 SEWHIELMLD 770 RGIPVELWAH 780 YVEELNSTQR 790 VAVEDSVFLV 800 FSLKKFIYAL 810 KAPKSFPKGD 820 IWWNPEQLKE 830 DSRDYLHLLI 840 GLFEMMLNGA 850 DAVHFRVLMK 860 LFIKVHLEDV 870 FQLFKFCSVL 880 WTYGSSLSNP 890 LNCSVKTVLQ 900 TQALYVGCAM 910 LSSQKTQCKH 920 QLASISSPVV 930 TSLLINLGSP 940 VKEVRRAAIQ 950 CLQALSGVAS 960 PFYLIIDHLI 970 SKAEEITSDA 980 AYVIQDLATL 990 FEELQREKKL 1000 KSHQKLSETL 1010 KNLLSCVYSC 1020 PSYIAKDLMK 1030 VLQGVNGEMV 1040 LSQLLPMAEQ 1050 LLEKIQKEPT 1060 AVLKDEAMVL 1070 HLTLGKYNEF 1080 SVSLLNEDPK 1090 SLDIFIKAVH 1100 TTKELYAGMP 1110 TIQITALEKI 1120 TKPFFAAISD 1130 EKVQQKLLRM 1140 LFDLLVNCKN 1150 SHCAQTVSSV 1160 FKGISVNAEQ 1170 VRIELEPPDK 1180 AKPLGTVQQK 1190 RRQKMQQKKS 1200 QDLESVQEVG 1210 GSYWQRVTLI 1220 LELLQHKKKL 1230 RSPQILVPTL 1240 FNLLSRCLEP 1250 LPQEQGNMEY 1260 TKQLILSCLL 1270 NICQKLSPDG 1280 GKIPKDILDE 1290 EKFNVELIVQ 1300 CIRLSEMPQT 1310 HHHALLLLGT 1320 VAGIFPDKVL 1330 HNIMSIFTFM 1340 GANVMRLDDT 1350 YSFQVINKTV 1360 KMVIPALIQS 1370 DSGDSIEVSR 1380 NVEEIVVKII 1390 SVFVDALPHV 1400 PEHRRLPILV 1410 QLVDTLGAEK 1420 FLWILLILLF 1430 EQYVTKTVLA 1440 AAYGEKDAIL 1450 EADTEFWFSV 1460 CCEFSVQHQI 1470 QSLMNILQYL 1480 LKLPEEKEET 1490 IPKAVSFNKS 1500 ESQEEMLQVF 1510 NVETHTSKQL 1520 RHFKFLSVSF 1530 MSQLLSSNNF 1540 LKKVVESGGP 1550 EILKGLEERL 1560 LETVLGYISA 1570 VAQSMERNAD 1580 KLTVKFWRAL 1590 LSKAYDLLDK 1600 VNALLPTETF 1610 IPVIRGLVGN 1620 PLPSVRRKAL 1630 DLLNNKLQQN 1640 ISWKKTIVTR 1650 FLKLVPDLLA 1660 IVQRKKKEGE 1670 EEQAINRQTA 1680 LYTLKLLCKN 1690 FGAENPDPFV 1700 PVLNTAVKLI 1710 APERKEEKNV 1720 LGSALLCIAE 1730 VTSTLEALAI 1740 PQLPSLMPSL 1750 LTTMKNTSEL 1760 VSSEVYLLSA 1770 LAALQKVVET 1780 LPHFISPYLE 1790 GILSQVIHLE 1800 KITSEMGSAS 1810 QANIRLTSLK 1820 KTLATTLAPR 1830 VLLPAIKKTY 1840 KQIEKNWKNH 1850 MGPFMSILQE 1860 HIGVMKKEEL 1870 TSHQSQLTAF 1880 FLEALDFRAQ 1890 HSENDLEEVG 1900 KTENCIIDCL 1910 VAMVVKLSEV 1920 TFRPLFFKLF 1930 DWAKTEDAPK 1940 DRLLTFYNLA 1950 DCIAEKLKGL 1960 FTLFAGHLVK 1970 PFADTLNQVN 1980 ISKTDEAFFD 1990 SENDPEKCCL 2000 LLQFILNCLY 2010 KIFLFDTQHF 2020 ISKERAEALM 2030 MPLVDQLENR 2040 LGGEEKFQER 2050 VTKHLIPCIA 2060 QFSVAMADDS 2070 LWKPLNYQIL 2080 LKTRDSSPKV 2090 RFAALITVLA 2100 LAEKLKENYI 2110 VLLPESIPFL 2120 AELMEDECEE 2130 VEHQCQKTIQ 2140 QLETVLGEPL QSYF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030686	90S preribosome
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0032040	small-subunit processome
Cellular Component	GO:0034455	t-UTP complex
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0030515	snoRNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0061351	neural precursor cell proliferation
Biological Process	GO:2000234	positive regulation of rRNA processing
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I
Biological Process	GO:1902570	protein localization to nucleolus
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0016072	rRNA metabolic process

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.