Search Results
Overview
| Uniprot ID | Q9H5V9 |
|---|---|
| Protein Name | STING ER exit protein |
| Gene Name | STEEP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | DSYAQNAKVIEKQLE |
| 187 | QNAKVIEKQLERKGM |
| 192 | IEKQLERKGMSKRRL |
Function
Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (PubMed:32690950). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950, PubMed:37832545)
Protein Sequence
10
MPKVVSRSVV
20
CSDTRDREEY
30
DDGEKPLHVY
40
YCLCGQMVLV
50
LDCQLEKLPM
60
RPRDRSRVID
70
AAKHAHKFCN
80
TEDEETMYLR
90
RPEGIERQYR
100
KKCAKCGLPL
110
FYQSQPKNAP
120
VTFIVDGAVV
130
KFGQGFGKTN
140
IYTQKQEPPK
150
KVMMTKRTKD
160
MGKFSSVTVS
170
TIDEEEEEIE
180
AREVADSYAQ
190
NAKVIEKQLE
200
RKGMSKRRLQ
210
ELAELEAKKA
220
KMKGTLIDNQ
FK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0090158 | endoplasmic reticulum membrane organization |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0032527 | protein exit from endoplasmic reticulum |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.