Search Results

Overview

Uniprot IDQ9H6F5
Protein NameCoiled-coil domain-containing protein 86
Gene NameCCDC86
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
237 EELPVIPKGKPKSGR
281 RQERKLAKDFARHLE
350 DTLALLQKQPPQQPA

Function

Required for proper chromosome segregation during mitosis and error-free mitotic progression

Protein Sequence

10 MDTPLRRSRR 20 LGGLRPESPE 30 SLTSVSRTRR 40 ALVEFESNPE 50 ETREPGSPPS 60 VQRAGLGSPE 70 RPPKTSPGSP 80 RLQQGAGLES 90 PQGQPEPGAA 100 SPQRQQDLHL 110 ESPQRQPEYS 120 PESPRCQPKP 130 SEEAPKCSQD 140 QGVLASELAQ 150 NKEELTPGAP 160 QHQLPPVPGS 170 PEPYPGQQAP 180 GPEPSQPLLE 190 LTPRAPGSPR 200 GQHEPSKPPP 210 AGETVTGGFG 220 AKKRKGSSSQ 230 APASKKLNKE 240 ELPVIPKGKP 250 KSGRVWKDRS 260 KKRFSQMLQD 270 KPLRTSWQRK 280 MKERQERKLA 290 KDFARHLEEE 300 KERRRQEKKQ 310 RRAENLKRRL 320 ENERKAEVVQ 330 VIRNPAKLKR 340 AKKKQLRSIE 350 KRDTLALLQK 360 QPPQQPAAKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0140014 mitotic nuclear division

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.