Search Results

Overview

Uniprot IDQ9H6R4
Protein NameNucleolar protein 6
Gene NameNOL6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
47 TLAEPPAKGLLQPVK
54 KGLLQPVKLSRAELY

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MGPAPAGEQL 20 RGATGEPEVM 30 EPALEGTGKE 40 GKKASSRKRT 50 LAEPPAKGLL 60 QPVKLSRAEL 70 YKEPTNEELN 80 RLRETEILFH 90 SSLLRLQVEE 100 LLKEVRLSEK 110 KKDRIDAFLR 120 EVNQRVVRVP 130 SVPETELTDQ 140 AWLPAGVRVP 150 LHQVPYAVKG 160 CFRFLPPAQV 170 TVVGSYLLGT 180 CIRPDINVDV 190 ALTMPREILQ 200 DKDGLNQRYF 210 RKRALYLAHL 220 AHHLAQDPLF 230 GSVCFSYTNG 240 CHLKPSLLLR 250 PRGKDERLVT 260 VRLHPCPPPD 270 FFRPCRLLPT 280 KNNVRSAWYR 290 GQSPAGDGSP 300 EPPTPRYNTW 310 VLQDTVLESH 320 LQLLSTILSS 330 AQGLKDGVAL 340 LKVWLRQREL 350 DKGQGGFTGF 360 LVSMLVVFLV 370 STRKIHTTMS 380 GYQVLRSVLQ 390 FLATTDLTVN 400 GISLCLSSDP 410 SLPALADFHQ 420 AFSVVFLDSS 430 GHLNLCADVT 440 ASTYHQVQHE 450 ARLSMMLLDS 460 RADDGFHLLL 470 MTPKPMIRAF 480 DHVLHLRPLS 490 RLQAACHRLK 500 LWPELQDNGG 510 DYVSAALGPL 520 TTLLEQGLGA 530 RLNLLAHSRP 540 PVPEWDISQD 550 PPKHKDSGTL 560 TLGLLLRPEG 570 LTSVLELGPE 580 ADQPEAAKFR 590 QFWGSRSELR 600 RFQDGAIREA 610 VVWEAASMSQ 620 KRLIPHQVVT 630 HLLALHADIP 640 ETCVHYVGGP 650 LDALIQGLKE 660 TSSTGEEALV 670 AAVRCYDDLS 680 RLLWGLEGLP 690 LTVSAVQGAH 700 PVLRYTEVFP 710 PTPVRPAFSF 720 YETLRERSSL 730 LPRLDKPCPA 740 YVEPMTVVCH 750 LEGSGQWPQD 760 AEAVQRVRAA 770 FQLRLAELLT 780 QQHGLQCRAT 790 ATHTDVLKDG 800 FVFRIRVAYQ 810 REPQILKEVQ 820 SPEGMISLRD 830 TAASLRLERD 840 TRQLPLLTSA 850 LHGLQQQHPA 860 FSGVARLAKR 870 WVRAQLLGEG 880 FADESLDLVA 890 AALFLHPEPF 900 TPPSSPQVGF 910 LRFLFLVSTF 920 DWKNNPLFVN 930 LNNELTVEEQ 940 VEIRSGFLAA 950 RAQLPVMVIV 960 TPQDRKNSVW 970 TQDGPSAQIL 980 QQLVVLAAEA 990 LPMLEKQLMD 1000 PRGPGDIRTV 1010 FRPPLDIYDV 1020 LIRLSPRHIP 1030 RHRQAVDSPA 1040 ASFCRGLLSQ 1050 PGPSSLMPVL 1060 GYDPPQLYLT 1070 QLREAFGDLA 1080 LFFYDQHGGE 1090 VIGVLWKPTS 1100 FQPQPFKASS 1110 TKGRMVMSRG 1120 GELVMVPNVE 1130 AILEDFAVLG 1140 EGLVQTVEAR SERWTV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0032545 CURI complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Cellular Component GO:0034456 UTP-C complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006364 rRNA processing
Biological Process GO:0006409 tRNA export from nucleus

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.