Search Results

Overview

Uniprot IDQ9H6S0
Protein Name3'-5' RNA helicase YTHDC2
Gene NameYTHDC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1200 WRSNNSRKSSADTEF
712 DSGKVKEKSFDALNF

Function

3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity)

Protein Sequence

10 MSRPSSVSPR 20 QPAPGGGGGG 30 GPSPCGPGGG 40 GRAKGLKDIR 50 IDEEVKIAVN 60 IALERFRYGD 70 QREMEFPSSL 80 TSTERAFIHR 90 LSQSLGLVSK 100 SKGKGANRYL 110 TVKKKDGSET 120 AHAMMTCNLT 130 HNTKHAVRSL 140 IQRFPVTNKE 150 RTELLPKTER 160 GNVFAVEAEN 170 REMSKTSGRL 180 NNGIPQIPVK 190 RGESEFDSFR 200 QSLPVFEKQE 210 EIVKIIKENK 220 VVLIVGETGS 230 GKTTQIPQFL 240 LDDCFKNGIP 250 CRIFCTQPRR 260 LAAIAVAERV 270 AAERRERIGQ 280 TIGYQIRLES 290 RVSPKTLLTF 300 CTNGVLLRTL 310 MAGDSTLSTV 320 THVIVDEVHE 330 RDRFSDFLLT 340 KLRDLLQKHP 350 TLKLILSSAA 360 LDVNLFIRYF 370 GSCPVIYIQG 380 RPFEVKEMFL 390 EDILRTTGYT 400 NKEMLKYKKE 410 KQQEEKQQTT 420 LTEWYSAQEN 430 SFKPESQRQR 440 TVLNVTDEYD 450 LLDDGGDAVF 460 SQLTEKDVNC 470 LEPWLIKEMD 480 ACLSDIWLHK 490 DIDAFAQVFH 500 LILTENVSVD 510 YRHSETSATA 520 LMVAAGRGFA 530 SQVEQLISMG 540 ANVHSKASNG 550 WMALDWAKHF 560 GQTEIVDLLE 570 SYSATLEFGN 580 LDESSLVQTN 590 GSDLSAEDRE 600 LLKAYHHSFD 610 DEKVDLDLIM 620 HLLYNICHSC 630 DAGAVLIFLP 640 GYDEIVGLRD 650 RILFDDKRFA 660 DSTHRYQVFM 670 LHSNMQTSDQ 680 KKVLKNPPAG 690 VRKIILSTNI 700 AETSITVNDV 710 VFVIDSGKVK 720 EKSFDALNFV 730 TMLKMVWISK 740 ASAIQRKGRA 750 GRCRPGICFR 760 LFSRLRFQNM 770 LEFQTPELLR 780 MPLQELCLHT 790 KLLAPVNCPI 800 ADFLMKAPEP 810 PPALIVRNAV 820 QMLKTIDAMD 830 TWEDLTELGY 840 HLADLPVEPH 850 LGKMVLCAVV 860 LKCLDPILTI 870 ACTLAYRDPF 880 VLPTQASQKR 890 AAMLCRKRFT 900 AGAFSDHMAL 910 LRAFQAWQKA 920 RSDGWERAFC 930 EKNFLSQATM 940 EIIIGMRTQL 950 LGQLRASGFV 960 RARGGGDIRD 970 VNTNSENWAV 980 VKAALVAGMY 990 PNLVHVDREN 1000 LVLTGPKEKK 1010 VRFHPASVLS 1020 QPQYKKIPPA 1030 NGQAAAIKAL 1040 PTDWLIYDEM 1050 TRAHRIANIR 1060 CCSAVTPVTI 1070 LVFCGPARLA 1080 SNALQEPSSF 1090 RVDGIPNDSS 1100 DSEMEDKTTA 1110 NLAALKLDEW 1120 LHFTLEPEAA 1130 SLLLQLRQKW 1140 HSLFLRRMRA 1150 PSKPWSQVDE 1160 ATIRAIIAVL 1170 STEEQSAGLQ 1180 QPSGIGQRPR 1190 PMSSEELPLA 1200 SSWRSNNSRK 1210 SSADTEFSDE 1220 CTTAERVLMK 1230 SPSPALHPPQ 1240 KYKDRGILHP 1250 KRGTEDRSDQ 1260 SSLKSTDSSS 1270 YPSPCASPSP 1280 PSSGKGSKSP 1290 SPRPNMPVRY 1300 FIMKSSNLRN 1310 LEISQQKGIW 1320 STTPSNERKL 1330 NRAFWESSIV 1340 YLVFSVQGSG 1350 HFQGFSRMSS 1360 EIGREKSQDW 1370 GSAGLGGVFK 1380 VEWIRKESLP 1390 FQFAHHLLNP 1400 WNDNKKVQIS 1410 RDGQELEPLV 1420 GEQLLQLWER 1430 LPLGEKNTTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0035770 ribonucleoprotein granule
Molecular Function GO:0034458 3'-5' RNA helicase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008186 ATP-dependent activity, acting on RNA
Molecular Function GO:0004386 helicase activity
Molecular Function GO:1990247 N6-methyladenosine-containing RNA reader activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0070063 RNA polymerase binding
Biological Process GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle
Biological Process GO:0044829 host-mediated activation of viral genome replication
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0048599 oocyte development
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:0007286 spermatid development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.