Search Results

Overview

Uniprot IDQ9H706
Protein NameGRB2-associated and regulator of MAPK protein 1
Gene NameGAREM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
91 VHYAGQFKLLEQDRD

Function

Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation

Protein Sequence

10 MDPAPSLGCS 20 LKDVKWSSVA 30 VPLDLLVSTY 40 RLPQIARLDN 50 GECVEGLREN 60 DYLLIHSCRQ 70 WTTITAHSLE 80 EGHYVIGPKI 90 EIPVHYAGQF 100 KLLEQDRDIK 110 EPVQYFNSVE 120 EVAKAFPERV 130 YVMEDITFNV 140 KVASGECNED 150 TEVYNITLCT 160 GDELTLMGQA 170 EILYAKTFKE 180 KSRLNTIFKK 190 IGKLNSISKL 200 GKGKMPCLIC 210 MNHRTNESIS 220 LPFQCKGRFS 230 TRSPLELQMQ 240 EGEHTIRNIV 250 EKTRLPVNVT 260 VPSPPPRNPY 270 DLHFIREGHR 280 YKFVNIQTKT 290 VVVCCVLRNN 300 KILPMHFPLH 310 LTVPKFSLPE 320 HLVKGESWPE 330 TLVHHWLGIC 340 QEQFDIDEYS 350 RAVRDVKTDW 360 NEECKSPKKG 370 RCSGHNHVPN 380 SLSYARDELT 390 QSFHRLSVCV 400 YGNNLHGNSE 410 VNLHGCRDLG 420 GDWAPFPHDI 430 LPYQDSGDSG 440 SDYLFPEASE 450 ESAGIPGKSE 460 LPYEELWLEE 470 GKPSHQPLTR 480 SLSEKNRCDQ 490 FRGSVRSKCA 500 TSPLPIPGTL 510 GAAVKSSDTA 520 LPPPPVPPKS 530 EAVREECRLL 540 NAPPVPPRSA 550 KPLSTSPSIP 560 PRTVKPARQQ 570 TRSPSPTLSY 580 YSSGLHNISV 590 TKTDTNPSES 600 TPVSCYPCNR 610 VKTDSVDLKS 620 PFGSPSAEAV 630 SSRLSWPNHY 640 SGASESQTRS 650 DFLLDPSRSY 660 SYPRQKTPGT 670 PKRNCPAPFD 680 FDGCELLASP 690 TSPVTAEFSS 700 SVSGCPKSAS 710 YSLESTDVKS 720 LAAGVTKQST 730 SCPALPPRAP 740 KLVEEKVASE 750 TSPLPLKIDG 760 AEEDPKSGSP 770 DLSEDQYFVK 780 KGMQDIFSAS 790 YPFSSPLHLQ 800 LAPRSCGDGS 810 PWQPPADLSG 820 LSIEEVSKSL 830 RFIGLSEDVI 840 SFFVTEKIDG 850 NLLVQLTEEI 860 LSEDFKLSKL 870 QVKKIMQFIN GWRPKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0070064 proline-rich region binding
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.