Search Results
Overview
| Uniprot ID | Q9H773 |
|---|---|
| Protein Name | dCTP pyrophosphatase 1 |
| Gene Name | DCTPP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | LARSSSRKYTELPHG |
Function
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism
Protein Sequence
10
MSVAGGEIRG
20
DTGGEDTAAP
30
GRFSFSPEPT
40
LEDIRRLHAE
50
FAAERDWEQF
60
HQPRNLLLAL
70
VGEVGELAEL
80
FQWKTDGEPG
90
PQGWSPRERA
100
ALQEELSDVL
110
IYLVALAARC
120
RVDLPLAVLS
130
KMDINRRRYP
140
AHLARSSSRK
150
YTELPHGAIS
160
EDQAVGPADI
170
PCDSTGQTST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0047840 | dCTP diphosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0047429 | nucleoside triphosphate diphosphatase activity |
| Molecular Function | GO:0032556 | pyrimidine deoxyribonucleotide binding |
| Biological Process | GO:0006253 | dCTP catabolic process |
| Biological Process | GO:0042262 | DNA protection |
| Biological Process | GO:0009143 | nucleoside triphosphate catabolic process |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.