Search Results
Overview
| Uniprot ID | Q9H788 |
|---|---|
| Protein Name | SH2 domain-containing protein 4A |
| Gene Name | SH2D4A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | FTNSLKTKSQYHDLQ |
| 266 | RLSLGAQKGRGGERL |
| 49 | REAAMERKESLPVKP |
Function
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function
Protein Sequence
10
MLKQILSEMY
20
IDPDLLAELS
30
EEQKQILFFK
40
MREEQIRRWK
50
EREAAMERKE
60
SLPVKPRPKK
70
ENGKSVHWKL
80
GADKEVWVWV
90
MGEHHLDKPY
100
DVLCNEIIAE
110
RARLKAEQEA
120
EEPRKTHSEE
130
FTNSLKTKSQ
140
YHDLQAPDNQ
150
QTKDIWKKVA
160
EKEELEQGSR
170
PAPTLEEEKI
180
RSLSSSSRNI
190
QQMLADSINR
200
MKAYAFHQKK
210
ESMKKKQDEE
220
INQIEEERTK
230
QICKSWKEDS
240
EWQASLRKSK
250
AADEKRRSLA
260
KQAREDYKRL
270
SLGAQKGRGG
280
ERLQSPLRVP
290
QKPERPPLPP
300
KPQFLNSGAY
310
PQKPLRNQGV
320
VRTLSSSAQE
330
DIIRWFKEEQ
340
LPLRAGYQKT
350
SDTIAPWFHG
360
ILTLKKANEL
370
LLSTGMPGSF
380
LIRVSERIKG
390
YALSYLSEDG
400
CKHFLIDASA
410
DAYSFLGVDQ
420
LQHATLADLV
430
EYHKEEPITS
440
LGKELLLYPC
450
GQQDQLPDYL
ELFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.