Search Results
Overview
| Uniprot ID | Q9H790 |
|---|---|
| Protein Name | Exonuclease V |
| Gene Name | EXO5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 222 | CFQVSLYKYIFDAMV |
Function
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity
Protein Sequence
10
MAETREEETV
20
SAEASGFSDL
30
SDSEFLEFLD
40
LEDAQESKAL
50
VNMPGPSSES
60
LGKDDKPISL
70
QNWKRGLDIL
80
SPMERFHLKY
90
LYVTDLATQN
100
WCELQTAYGK
110
ELPGFLAPEK
120
AAVLDTGASI
130
HLARELELHD
140
LVTVPVTTKE
150
DAWAIKFLNI
160
LLLIPTLQSE
170
GHIREFPVFG
180
EGEGVLLVGV
190
IDELHYTAKG
200
ELELAELKTR
210
RRPMLPLEAQ
220
KKKDCFQVSL
230
YKYIFDAMVQ
240
GKVTPASLIH
250
HTKLCLEKPL
260
GPSVLRHAQQ
270
GGFSVKSLGD
280
LMELVFLSLT
290
LSDLPVIDIL
300
KIEYIHQETA
310
TVLGTEIVAF
320
KEKEVRAKVQ
330
HYMAYWMGHR
340
EPQGVDVEEA
350
WKCRTCTYAD
360
ICEWRKGSGV
370
LSSTLAPQVK
KAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008310 | single-stranded DNA 3'-5' DNA exonuclease activity |
| Molecular Function | GO:0045145 | single-stranded DNA 5'-3' DNA exonuclease activity |
| Biological Process | GO:0036297 | interstrand cross-link repair |
Reference
PMID: N/A