Search Results

Overview

Uniprot IDQ9H792
Protein NameInactive tyrosine-protein kinase PEAK1
Gene NamePEAK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
673 EEIETESKVPDNTTS

Function

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654)

Protein Sequence

10 MSACNTFTEH 20 VWKPGECKNC 30 FKPKSLHQLP 40 PDPEKAPITH 50 GNVKTNANHS 60 NNHRIRNTGN 70 FRPPVAKKPT 80 IAVKPTMIVA 90 DGQSICGELS 100 IQEHCENKPV 110 IIGWNRNRAA 120 LSQKPLNNNN 130 EDDEGISHVP 140 KPYGNNDSAK 150 KMSDNNNGLT 160 EVLKEIAGLD 170 TAPQIRGNET 180 NSRETFLGRI 190 NDCYKRSLER 200 KLPPSCMIGG 210 IKETQGKHVI 220 LSGSTEVISN 230 EGGRFCYPEF 240 SSGEESEEDV 250 LFSNMEEEHE 260 SWDESDEELL 270 AMEIRMRGQP 280 RFANFRANTL 290 SPVRFFVDKK 300 WNTIPLRNKS 310 LQRICAVDYD 320 DSYDEILNGY 330 EENSVVSYGQ 340 GSIQSMVSSD 350 STSPDSSLTE 360 ESRSETASSL 370 SQKICNGGLS 380 PGNPGDSKDM 390 KEIEPNYESP 400 SSNNQDKDSS 410 QASKSSIKVP 420 ETHKAVLALR 430 LEEKDGKIAV 440 QTEKEESKAS 450 TDVAGQAVTI 460 NLVPTEEQAK 470 PYRVVNLEQP 480 LCKPYTVVDV 490 SAAMASEHLE 500 GPVNSPKTKS 510 SSSTPNSPVT 520 SSSLTPGQIS 530 AHFQKSSAIR 540 YQEVWTSSTS 550 PRQKIPKVEL 560 ITSGTGPNVP 570 PRKNCHKSAP 580 TSPTATNISS 590 KTIPVKSPNL 600 SEIKFNSYNN 610 AGMPPFPIII 620 HDEPTYARSS 630 KNAIKVPIVI 640 NPNAYDNLAI 650 YKSFLGTSGE 660 LSVKEKTTSV 670 ISHTYEEIET 680 ESKVPDNTTS 690 KTTDCLQTKG 700 FSNSTEHKRG 710 SVAQKVQEFN 720 NCLNRGQSSP 730 QRSYSSSHSS 740 PAKIQRATQE 750 PVAKIEGTQE 760 SQMVGSSSTR 770 EKASTVLSQI 780 VASIQPPQSP 790 PETPQSGPKA 800 CSVEELYAIP 810 PDADVAKSTP 820 KSTPVRPKSL 830 FTSQPSGEAE 840 APQTTDSPTT 850 KVQKDPSIKP 860 VTPSPSKLVT 870 SPQSEPPAPF 880 PPPRSTSSPY 890 HAGNLLQRHF 900 TNWTKPTSPT 910 RSTEAESVLH 920 SEGSRRAADA 930 KPKRWISFKS 940 FFRRRKTDEE 950 DDKEKEREKG 960 KLVGLDGTVI 970 HMLPPPPVQR 980 HHWFTEAKGE 990 SSEKPAIVFM 1000 YRCDPAQGQL 1010 SVDQSKARTD 1020 QAAVMEKGRA 1030 ENALLQDSEK 1040 KRSHSSPSQI 1050 PKKILSHMTH 1060 EVTEDFSPRD 1070 PRTVVGKQDG 1080 RGCTSVTTAL 1090 SLPELEREDG 1100 KEDISDPMDP 1110 NPCSATYSNL 1120 GQSRAAMIPP 1130 KQPRQPKGAV 1140 DDAIAFGGKT 1150 DQEAPNASQP 1160 TPPPLPKKMI 1170 IRANTEPISK 1180 DLQKSMESSL 1190 CVMANPTYDI 1200 DPNWDASSAG 1210 SSISYELKGL 1220 DIESYDSLER 1230 PLRKERPVPS 1240 AANSISSLTT 1250 LSIKDRFSNS 1260 MESLSSRRGP 1270 SCRQGRGIQK 1280 PQRQALYRGL 1290 ENREEVVGKI 1300 RSLHTDALKK 1310 LAVKCEDLFM 1320 AGQKDQLRFG 1330 VDSWSDFRLT 1340 SDKPCCEAGD 1350 AVYYTASYAK 1360 DPLNNYAVKI 1370 CKSKAKESQQ 1380 YYHSLAVRQS 1390 LAVHFNIQQD 1400 CGHFLAEVPN 1410 RLLPWEDPDD 1420 PEKDEDDMEE 1430 TEEDAKGETD 1440 GKNPKPCSEA 1450 ASSQKENQGV 1460 MSKKQRSHVV 1470 VITREVPCLT 1480 VADFVRDSLA 1490 QHGKSPDLYE 1500 RQVCLLLLQL 1510 CSGLEHLKPY 1520 HVTHCDLRLE 1530 NLLLVHYQPG 1540 GTAQGFGPAE 1550 PSPTSSYPTR 1560 LIVSNFSQAK 1570 QKSHLVDPEI 1580 LRDQSRLAPE 1590 IITATQYKKC 1600 DEFQTGILIY 1610 EMLHLPNPFD 1620 ENPELKEREY 1630 TRADLPRIPF 1640 RSPYSRGLQQ 1650 LASCLLNPNP 1660 SERILISDAK 1670 GILQCLLWGP 1680 REDLFQTFTA 1690 CPSLVQRNTL 1700 LQNWLDIKRT 1710 LLMIKFAEKS 1720 LDREGGISLE 1730 DWLCAQYLAF 1740 ATTDSLSCIV KILQHR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005925 focal adhesion
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004715 non-membrane spanning protein tyrosine kinase activity
Molecular Function GO:0004672 protein kinase activity
Biological Process GO:0016477 cell migration
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:2000145 regulation of cell motility
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.