Search Results

Overview

Uniprot IDQ9H7B2
Protein NameRibosome production factor 2 homolog
Gene NameRPF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
252 ALKPKKKKNISHDTF
270 YGRIHMQKQDLSKLQ
275 MQKQDLSKLQTRKMK

Function

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus

Protein Sequence

10 MDTLDRVVKP 20 KTKRAKRFLE 30 KREPKLNENI 40 KNAMLIKGGN 50 ANATVTKVLK 60 DVYALKKPYG 70 VLYKKKNITR 80 PFEDQTSLEF 90 FSKKSDCSLF 100 MFGSHNKKRP 110 NNLVIGRMYD 120 YHVLDMIELG 130 IENFVSLKDI 140 KNSKCPEGTK 150 PMLIFAGDDF 160 DVTEDYRRLK 170 SLLIDFFRGP 180 TVSNIRLAGL 190 EYVLHFTALN 200 GKIYFRSYKL 210 LLKKSGCRTP 220 RIELEEMGPS 230 LDLVLRRTHL 240 ASDDLYKLSM 250 KMPKALKPKK 260 KKNISHDTFG 270 TTYGRIHMQK 280 QDLSKLQTRK 290 MKGLKKRPAE 300 RITEDHEKKS KRIKKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0008097 5S rRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0019843 rRNA binding
Biological Process GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:1902570 protein localization to nucleolus
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0000027 ribosomal large subunit assembly
Biological Process GO:0042273 ribosomal large subunit biogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.