Search Results

Overview

Uniprot IDQ9H7D0
Protein NameDedicator of cytokinesis protein 5
Gene NameDOCK5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1741 RKDWSLSKSQVIAEK
1765 TRKAQRPKSLQLMDN
1859 PPPPKARKSGIPTSE

Function

Guanine nucleotide exchange factor (GEF) for Rho and Rac (PubMed:38857861). GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Together with ELMO1, activates RAC1; the activity is stimulated by RHOG (PubMed:38857861). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829)

Protein Sequence

10 MARWIPTKRQ 20 KYGVAIYNYN 30 ASQDVELSLQ 40 IGDTVHILEM 50 YEGWYRGYTL 60 QNKSKKGIFP 70 ETYIHLKEAT 80 VEDLGQHETV 90 IPGELPLVQE 100 LTSTLREWAV 110 IWRKLYVNNK 120 LTLFRQLQQM 130 TYSLIEWRSQ 140 ILSGTLPKDE 150 LAELKKKVTA 160 KIDHGNRMLG 170 LDLVVRDDNG 180 NILDPDETST 190 IALFKAHEVA 200 SKRIEEKIQE 210 EKSILQNLDL 220 RGQSIFSTIH 230 TYGLYVNFKN 240 FVCNIGEDAE 250 LFMALYDPDQ 260 STFISENYLI 270 RWGSNGMPKE 280 IEKLNNLQAV 290 FTDLSSMDLI 300 RPRVSLVCQI 310 VRVGHMELKE 320 GKKHTCGLRR 330 PFGVAVMDIT 340 DIIHGKVDDE 350 EKQHFIPFQQ 360 IAMETYIRQR 370 QLIMSPLITS 380 HVIGENEPLT 390 SVLNKVIAAK 400 EVNHKGQGLW 410 VSLKLLPGDL 420 TQVQKNFSHL 430 VDRSTAIARK 440 MGFPEIILPG 450 DVRNDIYVTL 460 IHGEFDKGKK 470 KTPKNVEVTM 480 SVHDEEGKLL 490 EKAIHPGAGY 500 EGISEYKSVV 510 YYQVKQPCWY 520 ETVKVSIAIE 530 EVTRCHIRFT 540 FRHRSSQETR 550 DKSERAFGVA 560 FVKLMNPDGT 570 TLQDGRHDLV 580 VYKGDNKKME 590 DAKFYLTLPG 600 TKMEMEEKEL 610 QASKNLVTFT 620 PSKDSTKDSF 630 QIATLICSTK 640 LTQNVDLLGL 650 LNWRSNSQNI 660 KHNLKKLMEV 670 DGGEIVKFLQ 680 DTLDALFNIM 690 MEMSDSETYD 700 FLVFDALVFI 710 ISLIGDIKFQ 720 HFNPVLETYI 730 YKHFSATLAY 740 VKLSKVLNFY 750 VANADDSSKT 760 ELLFAALKAL 770 KYLFRFIIQS 780 RVLYLRFYGQ 790 SKDGDEFNNS 800 IRQLFLAFNM 810 LMDRPLEEAV 820 KIKGAALKYL 830 PSIINDVKLV 840 FDPVELSVLF 850 CKFIQSIPDN 860 QLVRQKLNCM 870 TKIVESTLFR 880 QSECREVLLP 890 LLTDQLSGQL 900 DDNSNKPDHE 910 ASSQLLSNIL 920 EVLDRKDVGA 930 TAVHIQLIME 940 RLLRRINRTV 950 IGMNRQSPHI 960 GSFVACMIAL 970 LQQMDDSHYS 980 HYISTFKTRQ 990 DIIDFLMETF 1000 IMFKDLIGKN 1010 VYAKDWMVMN 1020 MTQNRVFLRA 1030 INQFAEVLTR 1040 FFMDQASFEL 1050 QLWNNYFHLA 1060 VAFLTHESLQ 1070 LETFSQAKRN 1080 KIVKKYGDMR 1090 KEIGFRIRDM 1100 WYNLGPHKIK 1110 FIPSMVGPIL 1120 EVTLTPEVEL 1130 RKATIPIFFD 1140 MMQCEFNFSG 1150 NGNFHMFENE 1160 LITKLDQEVE 1170 GGRGDEQYKV 1180 LLEKLLLEHC 1190 RKHKYLSSSG 1200 EVFALLVSSL 1210 LENLLDYRTI 1220 IMQDESKENR 1230 MSCTVNVLNF 1240 YKEKKREDIY 1250 IRYLYKLRDL 1260 HRDCENYTEA 1270 AYTLLLHAEL 1280 LQWSDKPCVP 1290 HLLQKDSYYV 1300 YTQQELKEKL 1310 YQEIISYFDK 1320 GKMWEKAIKL 1330 SKELAETYES 1340 KVFDYEGLGN 1350 LLKKRASFYE 1360 NIIKAMRPQP 1370 EYFAVGYYGQ 1380 GFPSFLRNKI 1390 FIYRGKEYER 1400 REDFSLRLLT 1410 QFPNAEKMTS 1420 TTPPGEDIKS 1430 SPKQYMQCFT 1440 VKPVMSLPPS 1450 YKDKPVPEQI 1460 LNYYRANEVQ 1470 QFRYSRPFRK 1480 GEKDPDNEFA 1490 TMWIERTTYT 1500 TAYTFPGILK 1510 WFEVKQISTE 1520 EISPLENAIE 1530 TMELTNERIS 1540 NCVQQHAWDR 1550 SLSVHPLSML 1560 LSGIVDPAVM 1570 GGFSNYEKAF 1580 FTEKYLQEHP 1590 EDQEKVELLK 1600 RLIALQMPLL 1610 TEGIRIHGEK 1620 LTEQLKPLHE 1630 RLSSCFRELK 1640 EKVEKHYGVI 1650 TLPPNLTERK 1660 QSRTGSIVLP 1670 YIMSSTLRRL 1680 SITSVTSSVV 1690 STSSNSSDNA 1700 PSRPGSDGSI 1710 LEPLLERRAS 1720 SGARVEDLSL 1730 REENSENRIS 1740 KFKRKDWSLS 1750 KSQVIAEKAP 1760 EPDLMSPTRK 1770 AQRPKSLQLM 1780 DNRLSPFHGS 1790 SPPQSTPLSP 1800 PPLTPKATRT 1810 LSSPSLQTDG 1820 IAATPVPPPP 1830 PPKSKPYEGS 1840 QRNSTELAPP 1850 LPVRREAKAP 1860 PPPPPKARKS 1870 GIPTSEPGSQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0016477 cell migration
Biological Process GO:0007520 myoblast fusion
Biological Process GO:1904694 negative regulation of vascular associated smooth muscle contraction
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:1904754 positive regulation of vascular associated smooth muscle cell migration
Biological Process GO:0016601 Rac protein signal transduction

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.