Search Results

Overview

Uniprot IDQ9H7L9
Protein NameSin3 histone deacetylase corepressor complex component SDS3
Gene NameSUDS3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 EYQKRMKKLDQQYKE
198 DPVPIPDKRRKPAPA
76 KEQMYQDKLASLKRQ

Function

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes

Protein Sequence

10 MSAAGLLAPA 20 PAQAGAPPAP 30 EYYPEEDEEL 40 ESAEDDERSC 50 RGRESDEDTE 60 DASETDLAKH 70 DEEDYVEMKE 80 QMYQDKLASL 90 KRQLQQLQEG 100 TLQEYQKRMK 110 KLDQQYKERI 120 RNAELFLQLE 130 TEQVERNYIK 140 EKKAAVKEFE 150 DKKVELKENL 160 IAELEEKKKM 170 IENEKLTMEL 180 TGDSMEVKPI 190 MTRKLRRRPN 200 DPVPIPDKRR 210 KPAPAQLNYL 220 LTDEQIMEDL 230 RTLNKLKSPK 240 RPASPSSPEH 250 LPATPAESPA 260 QRFEARIEDG 270 KLYYDKRWYH 280 KSQAIYLESK 290 DNQKLSCVIS 300 SVGANEIWVR 310 KTSDSTKMRI 320 YLGQLQRGLF VIRRRSAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0070822 Sin3-type complex
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042826 histone deacetylase binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.