Search Results

Overview

Uniprot IDQ9H7N4
Protein NameSplicing factor, arginine/serine-rich 19
Gene NameSCAF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1254 VHKICHSKSGEINPV
836 RKVKLQSKVAVLIRE

Function

May function in pre-mRNA splicing

Protein Sequence

10 MEEEDESRGK 20 TEESGEDRGD 30 GPPDRDPTLS 40 PSAFILRAIQ 50 QAVGSSLQGD 60 LPNDKDGSRC 70 HGLRWRRCRS 80 PRSEPRSQES 90 GGTDTATVLD 100 MATDSFLAGL 110 VSVLDPPDTW 120 VPSRLDLRPG 130 ESEDMLELVA 140 EVRIGDRDPI 150 PLPVPSLLPR 160 LRAWRTGKTV 170 SPQSNSSRPT 180 CARHLTLGTG 190 DGGPAPPPAP 200 SSASSSPSPS 210 PSSSSPSPPP 220 PPPPPAPPAP 230 PAPRFDIYDP 240 FHPTDEAYSP 250 PPAPEQKYDP 260 FEPTGSNPSS 270 SAGTPSPEEE 280 EEEEEEEEEE 290 EEDEEEEEGL 300 SQSISRISET 310 LAGIYDDNSL 320 SQDFPGDESP 330 RPDAQPTQPT 340 PAPGTPPQVD 350 STRADGAMRR 360 RVFVVGTEAE 370 ACREGKVSVE 380 VVTAGGAALP 390 PPLLPPGDSE 400 IEEGEIVQPE 410 EEPRLALSLF 420 RPGGRAARPT 430 PAASATPTAQ 440 PLPQPPAPRA 450 PEGDDFLSLH 460 AESDGEGALQ 470 VDLGEPAPAP 480 PAADSRWGGL 490 DLRRKILTQR 500 RERYRQRSPS 510 PAPAPAPAAA 520 AGPPTRKKSR 530 RERKRSGEAK 540 EAASSSSGTQ 550 PAPPAPASPW 560 DSKKHRSRDR 570 KPGSHASSSA 580 RRRSRSRSRS 590 RSTRRRSRST 600 DRRRGGSRRS 610 RSREKRRRRR 620 RSASPPPATS 630 SSSSSRRERH 640 RGKHRDGGGS 650 KKKKKRSRSR 660 GEKRSGDGSE 670 KAPAPAPPPS 680 GSTSCGDRDS 690 RRRGAVPPSI 700 QDLTDHDLFA 710 IKRTITVGRL 720 DKSDPRGPSP 730 APASSPKREV 740 LYDSEGLSGE 750 ERGGKSSQKD 760 RRRSGAASSS 770 SSSREKGSRR 780 KALDGGDRDR 790 DRDRDRDRDR 800 SSKKARPPKE 810 SAPSSGPPPK 820 PPVSSGSGSS 830 SSSSSCSSRK 840 VKLQSKVAVL 850 IREGVSSTTP 860 AKDAASAGLG 870 SIGVKFSRDR 880 ESRSPFLKPD 890 ERAPTEMAKA 900 APGSTKPKKT 910 KVKAKAGAKK 920 TKGTKGKTKP 930 SKTRKKVRSG 940 GGSGGSGGQV 950 SLKKSKADSC 960 SQAAGTKGAE 970 ETSWSGEERA 980 AKVPSTPPPK 990 AAPPPPALTP 1000 DSQTVDSSCK 1010 TPEVSFLPEE 1020 ATEEAGVRGG 1030 AEEEEEEEEE 1040 EEEEEEEEEQ 1050 QPATTTATST 1060 AAAAPSTAPS 1070 AGSTAGDSGA 1080 EDGPASRVSQ 1090 LPTLPPPMPW 1100 NLPAGVDCTT 1110 SGVLALTALL 1120 FKMEEANLAS 1130 RAKAQELIQA 1140 TNQILSHRKP 1150 PSSLGMTPAP 1160 VPTSLGLPPG 1170 PSSYLLPGSL 1180 PLGGCGSTPP 1190 TPTGLAATSD 1200 KREGSSSSEG 1210 RGDTDKYLKK 1220 LHTQERAVEE 1230 VKLAIKPYYQ 1240 KKDITKEEYK 1250 DILRKAVHKI 1260 CHSKSGEINP 1270 VKVSNLVRAY 1280 VQRYRYFRKH 1290 GRKPGDPPGP 1300 PRPPKEPGPP 1310 DKGGPGLPLP PL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0099122 RNA polymerase II C-terminal domain binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.