Overview
| Uniprot ID | Q9H7Z7 |
|---|
| Protein Name | Prostaglandin E synthase 2 |
|---|
| Gene Name | PTGES2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
AQQVYGGKEARTEEM |
Function
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783)
Protein Sequence
10
MDPAARVVRA
20
LWPGGCALAW
30
RLGGRPQPLL
40
PTQSRAGFAG
50
AAGGPSPVAA
60
ARKGSPRLLG
70
AAALALGGAL
80
GLYHTARWHL
90
RAQDLHAERS
100
AAQLSLSSRL
110
QLTLYQYKTC
120
PFCSKVRAFL
130
DFHALPYQVV
140
EVNPVRRAEI
150
KFSSYRKVPI
160
LVAQEGESSQ
170
QLNDSSVIIS
180
ALKTYLVSGQ
190
PLEEIITYYP
200
AMKAVNEQGK
210
EVTEFGNKYW
220
LMLNEKEAQQ
230
VYGGKEARTE
240
EMKWRQWADD
250
WLVHLISPNV
260
YRTPTEALAS
270
FDYIVREGKF
280
GAVEGAVAKY
290
MGAAAMYLIS
300
KRLKSRHRLQ
310
DNVREDLYEA
320
ADKWVAAVGK
330
DRPFMGGQKP
340
NLADLAVYGV
350
LRVMEGLDAF
360
DDLMQHTHIQ
370
PWYLRVERAI
TEASPAH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035578 |
azurophil granule lumen |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0036134 |
12-hydroxyheptadecatrienoic acid synthase activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0043295 |
glutathione binding |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0016829 |
lyase activity |
| Molecular Function |
GO:0050220 |
prostaglandin-E synthase activity |
| Biological Process |
GO:0019371 |
cyclooxygenase pathway |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0046457 |
prostanoid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.